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Invitrogen

ZFP36 Monoclonal Antibody (OTI1A2)

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ZFP36 Monoclonal Antibody (OTI1A2)

Product Details

MA5-25406

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:150
-

Immunocytochemistry (ICC/IF)

1:100
-

Flow Cytometry (Flow)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI1A2

Immunogen

Full length human recombinant protein of ZFP36 produced in HEK293T cell
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2725702

Target Information

ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: G0/G1 switch regulatory protein 24; Growth factor-inducible nuclear protein NUP475; mRNA decay activator protein ZFP36; TPA-induced sequence 11; Tristetraprolin; tristetraproline; unnamed protein product; Zfp-36; Zinc finger protein 36; zinc finger protein 36 homolog; zinc finger protein 36, C3H type, homolog

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Gene Aliases: G0S24; GOS24; NUP475; RNF162A; TIS11; TIS11A; TIS11D; TISII; TTP; Zfp-36; ZFP36

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UniProt ID: (Human) P26651, (Mouse) P22893

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Entrez Gene ID: (Human) 7538, (Mouse) 22695

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Function(s)
DNA binding RNA binding mRNA binding mRNA 3'-UTR binding protein binding zinc ion binding enzyme binding protein kinase binding C-C chemokine binding heat shock protein binding mRNA 3'-UTR AU-rich region binding macromolecular complex binding metal ion binding RNA polymerase binding 14-3-3 protein binding protein-RNA sequence-specific adaptor activity AU-rich element binding poly(A) RNA binding RNA metabolism protein
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay nuclear-transcribed mRNA poly(A) tail shortening mRNA catabolic process response to wounding regulation of keratinocyte proliferation gene silencing by RNA nuclear-transcribed mRNA catabolic process, deadenylation-independent decay regulation of tumor necrosis factor production negative regulation of interleukin-2 production negative regulation of viral transcription miRNA mediated inhibition of translation p38MAPK cascade response to starvation regulation of mRNA stability cellular response to fibroblast growth factor stimulus positive regulation of fat cell differentiation regulation of keratinocyte differentiation negative regulation of erythrocyte differentiation mRNA transport positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 3'-UTR-mediated mRNA destabilization 3'-UTR-mediated mRNA stabilization cellular response to lipopolysaccharide cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus cellular response to glucocorticoid stimulus cellular response to granulocyte macrophage colony-stimulating factor stimulus negative regulation of cytokine production involved in inflammatory response positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA regulation of keratinocyte apoptotic process negative regulation of polynucleotide adenylyltransferase activity positive regulation of intracellular mRNA localization negative regulation of 3'-UTR-mediated mRNA stabilization positive regulation of gene silencing by miRNA regulation of transcription from RNA polymerase II promoter intracellular signal transduction negative regulation of myeloid cell differentiation negative regulation of inflammatory response RNA destabilization
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