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Invitrogen
CTH Monoclonal Antibody (OTI1E12)
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FIGURE: 1 / 14
CTH Antibody (MA5-25423) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human endometrium tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a CTH monoclonal antibody (Product # MA5-25423).
Product Details
MA5-25423
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Rhesus monkey
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI1E12
Immunogen
Full length human recombinant protein of CTH produced in HEK293T cell
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CGL; cystathionase (cystathionine gamma-lyase); Cystathionine gamma-lyase; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; homoserine deaminase; homoserine dehydratase; MGC9471; unnamed protein product
Gene Aliases: CGL; CSE; CTH; EGK_00877
UniProt ID: (Human) B4E1R2
Entrez Gene ID: (Dog) 479991, (Rhesus monkey) 696664, (Human) 1491
cysteine metabolic process
lipid metabolic process
cellular amino acid biosynthetic process
protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
cysteine biosynthetic process via cystathionine
cysteine biosynthetic process
transsulfuration
endoplasmic reticulum unfolded protein response
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
protein sulfhydration
protein homotetramerization
hydrogen sulfide biosynthetic process
positive regulation of aortic smooth muscle cell differentiation
cellular response to leukemia inhibitory factor
negative regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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