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Invitrogen
Aldolase B Monoclonal Antibody (OTI3C6)
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FIGURE: 1 / 3
Aldolase B Antibody (MA5-25544) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded human kidney tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a ALDOB monoclonal antibody (Product # MA5-25544).
Product Details
MA5-25544
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI3C6
Immunogen
Full length human recombinant protein of ALDOB produced in HEK293 cell
Conjugate
Form
Liquid
Concentration
0.77 mg/mL
Amount
77 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Fructose-1,6-bisphosphate aldolase is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aldolase 2; aldolase B, fructose-bisphosphatase; aldolase B, fructose-bisphosphate; Fructose-bisphosphate aldolase B; Liver-type aldolase; unnamed protein product
Gene Aliases: ALDB; ALDO2; ALDOB
UniProt ID: (Human) P05062
Entrez Gene ID: (Human) 229
fructose metabolic process
fructose catabolic process
gluconeogenesis
glycolytic process
fructose 1,6-bisphosphate metabolic process
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
vacuolar proton-transporting V-type ATPase complex assembly
negative regulation of pentose-phosphate shunt
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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