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Invitrogen
ALDH3A2 Monoclonal Antibody (OTI2D3)
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Product Details
MA5-25636
Product Specifications
Species Reactivity
Dog,
Human,
Non-human primate,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI2D3
Immunogen
Full length human recombinant protein of ALDH3A2 produced in HEK293T cell
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Aldh3A2 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh3A2 catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Mutations in the Aldh3A2 gene cause Sjogren-Larrson syndrome, an inherited neurocutaneous disorder. Patients with this disorder display ichthyosis, mental retardation and spastic diplegia. The pathogenesis of the cutaneous and neurological symptoms is thought to result from abnormal lipid accumulation in the membranes of skin and brain, the formation of aldehyde Schiff base adducts with amine-containing lipids or proteins, or defective eicosanoid metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alcohol dehydrogenase family 3, subfamily A2; Aldehyde dehydrogenase 10; aldehyde dehydrogenase 3A2; Aldehyde dehydrogenase 4; Aldehyde dehydrogenase family 3 member A2; aldehyde dehydrogenase family 3, subfamily A2; ALDH3A2; DKFZp686E23276; Fatty aldehyde dehydrogenase; FLJ20851; Microsomal aldehyde dehydrogenase; msALDH; unnamed protein product
Gene Aliases: ALDH10; ALDH3A2; Aldh4; FALDH; SLS
UniProt ID: (Human) P51648, (Rat) P30839
Entrez Gene ID: (Dog) 100688308, (Human) 224, (Rat) 65183
3-chloroallyl aldehyde dehydrogenase activity
aldehyde dehydrogenase (NAD) activity
protein binding
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
protein homodimerization activity
long-chain-alcohol oxidase activity
long-chain-aldehyde dehydrogenase activity
medium-chain-aldehyde dehydrogenase activity
fatty aldehyde dehydrogenase (NAD+) activity
aldehyde dehydrogenase [NAD(P)+] activity
dehydrogenase
cellular aldehyde metabolic process
lipid metabolic process
fatty acid metabolic process
sesquiterpenoid metabolic process
central nervous system development
peripheral nervous system development
epidermis development
phytol metabolic process
hexadecanal metabolic process
response to reactive oxygen species
formaldehyde metabolic process
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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