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Invitrogen
NEK9 Monoclonal Antibody (OTI1H1)
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Product Details
MA5-25650
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI1H1
Immunogen
Full length human recombinant protein of NEK9 produced in HEK293 cell
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
NEK9, a NEK type protein kinase, regulates chromosome alignment and segregation in mitosis. The protein has a N-terminal NIMA-like catalytic domain, a central domain with homology to the guanine nucleotide exchange factor for the GTPase Ran (RCC1), and a C-terminal coiled-coil domain. It is phosphorylated by active p34(Cdc2) and is capable of autophosphorylation and oligomerization. The activated protein binds Nek6 and RCC1, and has been shown to associate with the human homolog of the Drosophila protein Bicaudal D (Bicd2) in vivo and to phosphorylate this coiled-coil protein in vitro. NEK9 expression has been documented in normal human brain. ESTs have been isolated from several tissue libraries, including normal bone, lymph and thymus and cancerous cervix, eye, lymph and placenta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp434D0935; MGC138306; MGC16714; NEK 9; Nek8; Nercc 1 kinase; Nercc1 kinase; Never in mitosis A-related kinase 9; NIMA (never in mitosis gene a)- related kinase 9; NimA-related kinase 8; NimA-related protein kinase 9; Serine/threonine-protein kinase Nek9; unnamed protein product
Gene Aliases: APUG; KIAA1995; LCCS10; NC; NEK8; NEK9; NERCC; NERCC1
UniProt ID: (Human) Q8TD19
Entrez Gene ID: (Human) 91754
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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