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Invitrogen
DNM1L Monoclonal Antibody (OTI4F6)
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FIGURE: 1 / 13
DNM1L Antibody (MA5-26255) in ICC/IF
Immunofluorescence analysis of DNM1L was performed using 70% confluent log phase SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with DNM1L Monoclonal Antibody (OTI4F6) (Product # MA5-26255) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Recombinant Secondary Antibody, Alexa Fluor® 488 conjuga... View More
Product Details
MA5-26255
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Non-human primate,
Rat
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI4F6
Immunogen
Full length human recombinant protein of DNM1L produced in HEK293T cell
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
A human dynamin-related protein, DRP1 contributes to mitochondrial division in mammalian cells. It plays this important role in mitochondrial fission at steady state and during apoptosis. DRP1 is required for proper cellular distribution of mitochondria, and in mutant neurons, mitochondria are largely absent from synapses, thus providing a genetic tool to assess the role of mitochondria at synapses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-terminal region; Dnm1p/Vps1p-like protein; DVLP; Dymple; Dynamin family member proline-rich carboxyl-terminal domain less; Dynamin-1-like protein; Dynamin-like protein; dynamin-like protein 1; Dynamin-like protein 4; Dynamin-like protein IV; Dynamin-related protein 1; DYNIV 11; DYNIV-11; EC 3.6.5.5; FLJ41912; HdynIV; large G-protein; N-terminal region; putative GTP-binding protein; unnamed protein product; VPS1
Gene Aliases: 6330417M19Rik; AI450666; DLP1; DNM1L; Dnml1; Dnmlp1; DRP1; DVLP; DYMPLE; EMPF; EMPF1; HDYNIV; OPA5; python
UniProt ID: (Human) O00429, (Rat) O35303, (Mouse) Q8K1M6
Entrez Gene ID: (Human) 10059, (Dog) 477649, (Rat) 114114, (Mouse) 74006
nucleotide binding
GTPase activity
GTPase activator activity
protein binding
GTP binding
microtubule binding
lipid binding
hydrolase activity
GTP-dependent protein binding
small GTPase binding
ubiquitin protein ligase binding
identical protein binding
protein homodimerization activity
membrane traffic protein
mitochondrial fission
calcium ion transport
endocytosis
mitochondrion organization
endoplasmic reticulum organization
regulation of gene expression
regulation of mitochondrion organization
programmed cell death
peroxisome fission
mitochondrial fragmentation involved in apoptotic process
intracellular distribution of mitochondria
rhythmic process
positive regulation of protein secretion
protein oligomerization
heart contraction
protein localization to mitochondrion
positive regulation of neutrophil chemotaxis
positive regulation of mitochondrial fission
mitochondrial membrane fission
mitocytosis
regulation of peroxisome organization
regulation of mitophagy
positive regulation of secretion by cell
regulation of ATP metabolic process
release of cytochrome c from mitochondria
dynamin polymerization involved in mitochondrial fission
metabolic process
regulation of protein oligomerization
positive regulation of apoptotic process
protein homotetramerization
membrane fusion
necroptotic process
mitochondrion morphogenesis
positive regulation of release of cytochrome c from mitochondria
regulation of mitophagy
positive regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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