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Invitrogen
FBXW7 Monoclonal Antibody (OTI2G7)
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FIGURE: 1 / 7
FBXW7 Antibody (MA5-26558) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human endometrium tissue. To expose target proteins, 10mM citric buffer, pH6.0, 120°C for 3min was used. Following antigen retrieval, tissues were probed with a FBXW7 monoclonal antibody (Product # MA5-26558).
Product Details
MA5-26558
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI2G7
Immunogen
Human recombinant protein fragment corresponding to amino acids 1-354 of FBXW7 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXW7 was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: archipelago; Archipelago homolog; DKFZp686F23254; F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box and WD-40 domain-containing protein 7; F-box protein FBW7; F-box protein FBX30; F-box protein SEL-10; F-box/WD repeat-containing protein 7; FLJ11071; FLJ16457; hAgo; hCdc4; hCDC4; WD40 repeat-containing F-box protein; homolog of C elegans sel-10; SEL-10; similar to budding yeast CDC4; unnamed protein product; WD40 repeat-containing F-box protein
Gene Aliases: AGO; CDC4; DEDHIL; FBW6; FBW7; FBX30; FBXO30; FBXW6; FBXW7; hAgo; hCdc4; SEL-10; SEL10
UniProt ID: (Human) Q969H0
Entrez Gene ID: (Human) 55294
G1/S transition of mitotic cell cycle
vasculature development
DNA repair
cellular response to DNA damage stimulus
sister chromatid cohesion
regulation of mitotic cell cycle
negative regulation of gene expression
negative regulation of triglyceride biosynthetic process
regulation of lipid storage
ubiquitin homeostasis
protein ubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein ubiquitination
regulation of protein stability
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of protein localization
cellular response to UV
regulation of circadian rhythm
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of epidermal growth factor receptor signaling pathway
negative regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
protein stabilization
lipid homeostasis
positive regulation of ERK1 and ERK2 cascade
regulation of mitophagy
positive regulation of proteasomal protein catabolic process
regulation of cell cycle G1/S phase transition
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
positive regulation of protein targeting to mitochondrion
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of hepatocyte proliferation
negative regulation of SREBP signaling pathway
negative regulation of osteoclast development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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