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Invitrogen
IGF2BP3 Monoclonal Antibody (OTI6A3)
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FIGURE: 1 / 8
IGF2BP3 Antibody (MA5-27484) in ICC/IF
Immunofluorescence analysis of IGF2BP3 was performed using IMR-32 and MCF7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with IGF2BP3 Mouse Monoclonal Antibody (Product # MA5-27484) at 1:100 dilution in 0.1% BSA and incubated overnight at 4 degree and then labeled with Goat anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32723) at a diluti... View More
Product Details
MA5-27484
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI6A3
Immunogen
Full length human recombinant protein of IGF2BP3 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies. IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cancer/testis antigen 98; hKOC; IGF-II mRNA-binding protein 3; IGF2 mRNA-binding protein 3; insulin-l; Insulin-like growth factor 2 mRNA-binding protein 3; insulin-like growth factor 2, binding protein 3; KH domain containing protein overexpressed in cancer; KH domain-containing protein overexpressed in cancer; Kh-domain containing protein; mIMP-3; VICKZ family member 3
Gene Aliases: 2610101N11Rik; AA522010; Ab2-255; AL022933; AU045931; CT98; IGF2BP3; IMP-3; IMP3; KOC; KOC1; Koc13; mimp3; Neilsen; RGD1306512; VICKZ3
UniProt ID: (Human) O00425, (Mouse) Q9CPN8
Entrez Gene ID: (Human) 10643, (Mouse) 140488, (Rat) 312320
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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