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Invitrogen

YAP1 Monoclonal Antibody (GT256)

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YAP1 Monoclonal Antibody (GT256)

Product Details

MA5-27808

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

GT256

Immunogen

Recombinant protein encompassing a sequence within the N-terminus region of human YAP1. The exact sequence is proprietary.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.68 mg/mL

Amount

168 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2735413

Product Specific Information

Positive Control: HeLa, HepG2

Predicted Reactivity: Rat (96%), Zebrafish (87%), Xenopus laevis (81%), Chicken (84%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. YAP can act both as a coactivator and corepressor and is the critical downstream regulatory target in the Hippo signaling pathway. The Hippo signaling pathway plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. Also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and cell migration. Mutations in the IRF5 gene results in coloboma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 65 kDa Yes-associated protein; Protein yorkie homolog; transcriptional co-activator; Transcriptional coactivator YAP1; unnamed protein product; Yes associated protein 1; Yes-associated protein 1; yes-associated protein 2; Yes-associated protein YAP65 homolog; yes-associated protein, 65 kDa; yorkie homolog

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Gene Aliases: AI325207; COB1; YAP; YAP-1; YAP1; YAP2; YAP65; YKI; Yorkie

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UniProt ID: (Human) P46937, (Mouse) P46938

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Entrez Gene ID: (Human) 10413, (Mouse) 22601

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding chromatin binding transcription cofactor activity transcription coactivator activity transcription corepressor activity protein binding proline-rich region binding DNA-binding transcription factor binding RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding protein C-terminus binding transcription regulatory region DNA binding transcription cofactor
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis vasculogenesis blastocyst development trophectodermal cell differentiation tissue homeostasis glandular epithelial cell differentiation heart process embryonic heart tube morphogenesis cellular response to DNA damage stimulus cell proliferation positive regulation of cell proliferation regulation of gene expression positive regulation of gene expression negative regulation of gene expression regulation of keratinocyte proliferation keratinocyte differentiation positive regulation of cell growth epithelial cell differentiation negative regulation of epithelial cell differentiation polarized epithelial cell differentiation notochord development response to progesterone somatic stem cell population maintenance organ growth hippo signaling wound healing regulation of cell proliferation negative regulation of fat cell differentiation positive regulation of osteoblast differentiation positive regulation of Notch signaling pathway positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of organ growth paraxial mesoderm development lateral mesoderm development epithelial cell proliferation positive regulation of epithelial cell proliferation regulation of neurogenesis positive regulation of cardiac muscle cell proliferation canonical Wnt signaling pathway bud elongation involved in lung branching lung epithelial cell differentiation intestinal epithelial cell differentiation intestinal epithelial cell development regulation of canonical Wnt signaling pathway cardiac muscle tissue regeneration canonical glycolysis protein-containing complex assembly interleukin-6-mediated signaling pathway cellular response to retinoic acid cellular response to gamma radiation regulation of stem cell proliferation regulation of metanephric nephron tubule epithelial cell differentiation positive regulation of canonical Wnt signaling pathway extrinsic apoptotic signaling pathway positive regulation of protein localization to nucleus negative regulation of cilium assembly positive regulation of stem cell population maintenance enterocyte differentiation negative regulation of epithelial cell apoptotic process negative regulation of stem cell differentiation negative regulation of extrinsic apoptotic signaling pathway transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter contact inhibition negative regulation of nucleic acid-templated transcription
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