Search
Invitrogen
FOXP2 Monoclonal Antibody (CL5312)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 9
FOXP2 Antibody (MA5-31419) in ICC/IF
Immunofluorecent analysis of FOXP2 in RH-30 cells using FOXP2 Monoclonal Antibody (CL5312) (Product # MA5-31419). Staining shows specific staining in the nucleoplasm in green. Microtubule- and nuclear probes are visualized in red and blue, respectively (where available).
Product Details
MA5-31419
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
CL5312
Immunogen
Recombinant protein fragment of Human FOXP2 (Product #RP-95090).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AQQLVFQQQL LQMQQLQQQQ HLLSLQRQGL ISIPPGQAAL PVQSLPQAGL SPAEIQQLWK EVTGVHSMED NGIKHGGLDL TTNNSSSTTS SNTSKASPPI THHS
Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 97%.
Target Information
FOXP2 is a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alternatively spliced; alternatively spliced; 3' end may have intronic sequence; CAG repeat protein 44; DKFZp686H1726; Forkhead box protein P2; forkhead/winged-helix transcription factor; FOXP2; FOXP2-S; alternatively spliced; OTTHUMP00000196932; trinucleotide repeat containing 10; Trinucleotide repeat-containing gene 10 protein; truncated splice variant; unnamed protein product
Gene Aliases: 2810043D05Rik; AI449000; CAG-16; CAGH44; D0Kist7; FOXP2; RGD1559697; SPCH1; TNRC10
UniProt ID: (Human) O15409, (Mouse) P58463, (Rat) P0CF24
Entrez Gene ID: (Human) 93986, (Mouse) 114142, (Rat) 500037
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
identical protein binding
protein homodimerization activity
sequence-specific DNA binding
metal ion binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein heterodimerization activity
negative regulation of transcription from RNA polymerase II promoter
positive regulation of mesenchymal cell proliferation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
skeletal muscle tissue development
post-embryonic development
gene expression
cerebellum development
cerebellar Purkinje cell differentiation
caudate nucleus development
putamen development
cerebral cortex development
lung development
vocal learning
camera-type eye development
negative regulation of transcription, DNA-templated
lung alveolus development
animal organ development
smooth muscle tissue development
positive regulation of epithelial cell proliferation
righting reflex
positive regulation of epithelial cell proliferation involved in lung morphogenesis
epithelial cell proliferation involved in lung morphogenesis
vocalization behavior
transcription, DNA-templated
transcription from RNA polymerase II promoter
embryo development
growth
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support