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Invitrogen

SQSTM1 Monoclonal Antibody (GT239)

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View all (91) SQSTM1 antibodies

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Product Details

MA5-31498

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:2,000
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

GT239

Immunogen

Recombinant protein encompassing a sequence within the center region of human SQSTM1/P62. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2787129

Product Specific Information

Keep as concentrated solution.

Positive Control: HepG2, A549, H1299, Huh-7 (untreated), Huh-7 (3 µM Thapsigargin treatment for 12 hr), Huh-7 (3 µM Thapsigargin treatment for 24 hr), HepG2 (3 µM Thapsigargin treatment for 12 hr), HepG2 (3 µM Thapsigargin treatment for 24 hr), PC-12.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: autophagy receptor p62; EBI3-associated protein of 60 kDa; EBI3-associated protein p60; EBIAP; oxidative stress induced; oxidative stress induced like; p62; p62 transcript variant 4; p62 transcript variant 5; phosphotyrosine independent ligand for the Lck SH2 domain p62; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; PKC-zeta-interacting protein; Protein kinase C-zeta-interacting protein; Sequestosome-1; STONE14; Ubiquitin-binding protein p62; unnamed protein product

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Gene Aliases: A170; DMRV; EBIAP; FTDALS3; NADGP; ORCA; OSF-6; Osi; OSIL; p60; p62; p62B; PDB3; SQSTM1; STAP; STONE14; ZIP; ZIP3

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UniProt ID: (Human) Q13501, (Rat) O08623, (Mouse) Q64337

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Entrez Gene ID: (Human) 8878, (Rat) 113894, (Mouse) 18412

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Function(s)
protein kinase C binding protein binding zinc ion binding enzyme binding protein kinase binding protein binding, bridging receptor tyrosine kinase binding ubiquitin protein ligase binding ionotropic glutamate receptor binding signaling receptor activity SH2 domain binding identical protein binding ubiquitin binding macromolecular complex binding metal ion binding K63-linked polyubiquitin binding ubiquitin-dependent protein binding protein sequestering activity molecular sequestering activity molecular condensate scaffold activity protein homodimerization activity transcription cofactor activity
Process(es)
positive regulation of protein phosphorylation immune system process ubiquitin-dependent protein catabolic process autophagy apoptotic process macroautophagy positive regulation of macroautophagy cell differentiation regulation of I-kappaB kinase/NF-kappaB signaling protein heterooligomerization regulation of mitophagy negative regulation of transcription from RNA polymerase II promoter mitophagy mitophagy pexophagy temperature homeostasis response to ischemia transcription from RNA polymerase II promoter protein import into nucleus endosome organization protein localization positive regulation of autophagy regulation of mitochondrion organization endosomal transport protein catabolic process negative regulation of protein ubiquitination cellular response to stress toll-like receptor 4 signaling pathway negative regulation of toll-like receptor 4 signaling pathway intracellular signal transduction aggrephagy positive regulation of apoptotic process positive regulation of transcription from RNA polymerase II promoter regulation of Ras protein signal transduction regulation of protein complex stability brown fat cell proliferation protein K63-linked ubiquitination protein targeting to vacuole involved in autophagy energy homeostasis response to mitochondrial depolarisation negative regulation of ferroptosis membraneless organelle assembly positive regulation of long-term synaptic potentiation positive regulation of protein localization to plasma membrane protein localization to perinuclear region of cytoplasm mitophagy in response to mitochondrial depolarization regulation of nucleic acid-templated transcription
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