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Invitrogen
RAD21 Monoclonal Antibody (1B6D1)
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FIGURE: 1 / 8
RAD21 Antibody (MA5-31884) in ICC/IF
Immunocytochemistry analysis of RAD21 in Hela cells (green). Sample was incubated with RAD21 monoclonal antibody (Product # MA5-31884) using a dilution of 1:200-1:1000 followed by DRAQ5 fluorescent DNA dye (blue), and Alexa Fluor- 555 phalloidin (red labeled actin filaments) .
Product Details
MA5-31884
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B6D1
Immunogen
Purified recombinant fragment of human RAD21 (AA: 287-403) expressed in E. coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-31884 has been tested in indirect ELISA.
Target Information
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Double-strand-break repair protein rad21 homolog; FLJ25655; FLJ40596; h NXP-1; hHR21; HR21spA; KIAA0078; KIAA0078RAD21; kleisin; Nuclear matrix protein 1; NXP-1; protein involved in DNA double-strand break repair; RAD21 homolog; SCC1 homolog; sister chromatid cohesion 1; unnamed protein product
Gene Aliases: CDLS4; hHR21; HR21; HRAD21; KIAA0078; MCD1; MGS; NXP1; RAD21; SCC1
UniProt ID: (Human) O60216
Entrez Gene ID: (Human) 5885, (Rat) 314949
response to hypoxia
DNA repair
double-strand break repair
DNA recombination
regulation of transcription from RNA polymerase II promoter
apoptotic process
cellular response to DNA damage stimulus
chromosome segregation
sister chromatid cohesion
reciprocal meiotic recombination
positive regulation of gene expression
negative regulation of gene expression
negative regulation of G2/M transition of mitotic cell cycle
negative regulation of interleukin-1 beta production
negative regulation of tumor necrosis factor production
positive regulation of interleukin-10 production
establishment of mitotic sister chromatid cohesion
establishment of meiotic sister chromatid cohesion
negative regulation of glial cell apoptotic process
negative regulation of neuron apoptotic process
negative regulation of mitotic metaphase/anaphase transition
positive regulation of sister chromatid cohesion
cell division
protein localization to chromatin
chromatin looping
replication-born double-strand break repair via sister chromatid exchange
transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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