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Invitrogen

CCR7 Recombinant Rabbit Monoclonal Antibody (SR36-04)

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CCR7 Recombinant Rabbit Monoclonal Antibody (SR36-04)

Product Details

MA5-31992

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:5,000
View 1 publication 1 publication

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:200-1:500
-

Inhibition Assays (Inhibition)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SR36-04

Immunogen

Synthetic peptide within Human CCR7 aa 13-62.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.021 mg/mL

Amount

202.1 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809286

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of naive from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC's. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: BLR2; Bukitt's lymphoma receptor 2; C-C chemokine receptor type 7; C-C CKR-7; CC chemokine receptor 7; CD197; CDw197; chemokine (C-C motif) receptor 7; chemokine (C-C) receptor 7; EBI1; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus-induced G-protein coupled receptor 1; G-protein coupled receptor; CCR7; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor; unnamed protein product

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Gene Aliases: BLR2; CC-CKR-7; CCR-7; CCR7; CD197; CDw197; CMKBR7; EBI1; Ebi1h; EVI1

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UniProt ID: (Human) P32248, (Mouse) P47774

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Entrez Gene ID: (Human) 1236, (Rat) 287673, (Mouse) 12775

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Function(s)
G-protein coupled receptor activity chemokine receptor activity C-C chemokine receptor activity chemokine (C-C motif) ligand 19 binding chemokine (C-C motif) ligand 21 binding C-C motif chemokine 19 receptor activity C-C motif chemokine 21 receptor activity signal transducer activity protein binding
Process(es)
myeloid dendritic cell chemotaxis positive regulation of dendritic cell antigen processing and presentation positive regulation of hypersensitivity positive regulation of humoral immune response chemotaxis inflammatory response immune response G-protein coupled receptor signaling pathway response to lipopolysaccharide regulation of interferon-gamma production positive regulation of interleukin-12 production chemokine (C-C motif) ligand 19 signaling pathway chemokine (C-C motif) ligand 21 signaling pathway negative thymic T cell selection regulation of interleukin-1 beta secretion positive regulation of T cell receptor signaling pathway chemokine-mediated signaling pathway cellular response to cytokine stimulus interleukin-12 secretion positive regulation of neutrophil chemotaxis mature conventional dendritic cell differentiation positive regulation of dendritic cell chemotaxis positive regulation of immunological synapse formation positive regulation of T cell costimulation positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation establishment of T cell polarity lymphocyte chemotaxis across high endothelial venule regulation of tolerance induction to self antigen signal transduction activation of JUN kinase activity positive regulation of macrophage chemotaxis positive regulation of T cell chemotaxis actin cytoskeleton organization positive regulation of tumor necrosis factor production response to prostaglandin E positive regulation of T cell proliferation positive regulation of GTPase activity positive regulation of T-helper 1 cell differentiation positive regulation of receptor-mediated endocytosis lymph node development positive regulation of interleukin-1 beta secretion positive regulation of phagocytosis positive regulation of filopodium assembly response to nitric oxide lymphocyte migration into lymph node negative regulation of leukocyte apoptotic process positive regulation of cell motility positive regulation of thymocyte migration regulation of dendritic cell dendrite assembly positive regulation of cell-matrix adhesion dendritic cell chemotaxis positive regulation of cytosolic calcium ion concentration calcium-mediated signaling positive regulation of actin filament polymerization positive regulation of pseudopodium assembly ruffle organization regulation of Cdc42 protein signal transduction regulation of interleukin-1 beta production negative regulation of interleukin-12 production positive regulation of Rac protein signal transduction CCL19-activated CCR7 signaling pathway CCL21-activated CCR7 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cell adhesion positive regulation of JNK cascade homeostasis of number of cells release of sequestered calcium ion into cytosol positive regulation of protein kinase B signaling cell chemotaxis positive regulation of ERK1 and ERK2 cascade cellular response to prostaglandin E stimulus positive regulation of phospholipase C/protein kinase C signal transduction negative regulation of dendritic cell apoptotic process
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