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Invitrogen
MMP12 Recombinant Rabbit Monoclonal Antibody (SR03-23)
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Product Details
MA5-32011
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SR03-23
Immunogen
Synthetic peptide within Human MMP12 aa 421-470.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22. 3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3.4.24.65; Macrophage elastase; Macrophage metalloelastase; macrophage-metalloelastase; matrix metallo protease; matrix metallopeptidase 12 (macrophage elastase); matrix metalloproteinase 12; matrix metalloproteinase 12 (macrophage elastase); Matrix metalloproteinase-12; ME; MGC138506; MME; MMP; MMP-12; MMPs; unnamed protein product
Gene Aliases: AV378681; HME; ME; MME; Mmel; MMP-12; MMP12
UniProt ID: (Human) P39900, (Mouse) P34960, (Rat) Q63341
Entrez Gene ID: (Human) 4321, (Mouse) 17381, (Rat) 117033
core promoter sequence-specific DNA binding
endopeptidase activity
metalloendopeptidase activity
serine-type endopeptidase activity
calcium ion binding
collagen binding
peptidase activity
metallopeptidase activity
zinc ion binding
hydrolase activity
sequence-specific DNA binding
metal ion binding
metalloprotease
negative regulation of transcription from RNA polymerase II promoter
proteolysis
protein import into nucleus
positive regulation of gene expression
extracellular matrix disassembly
extracellular matrix organization
collagen catabolic process
positive regulation of interferon-alpha production
wound healing, spreading of epidermal cells
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
regulation of defense response to virus by host
positive regulation of epithelial cell proliferation involved in wound healing
elastin catabolic process
negative regulation of type I interferon-mediated signaling pathway
positive regulation of type I interferon-mediated signaling pathway
bronchiole development
cellular response to virus
response to amyloid-beta
negative regulation of endothelial cell-matrix adhesion via fibronectin
wound healing
response to organic cyclic compound
response to drug
positive regulation of epithelial cell proliferation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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