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Invitrogen

CD51 Recombinant Rabbit Monoclonal Antibody (SC56-07)

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View all (37) Integrin alpha V (CD51) antibodies

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CD51 Recombinant Rabbit Monoclonal Antibody (SC56-07)

Product Details

MA5-32195

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2000-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000
-

Immunocytochemistry (ICC/IF)

1:50-1:100
View 1 publication 1 publication

Flow Cytometry (Flow)

1:50-1:100
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SC56-07

Immunogen

Synthetic peptide within of Human Integrin alpha V aa 1000-1048.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809482

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: alpha v integrin; antigen identified by monoclonal antibody L230; CD51; Dnmt3l-ps1 pseudogene; Integrin alpha-V; integrin alphaVbeta3; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); unnamed protein product; vitronectin alpha subunit precursor; Vitronectin receptor; vitronectin receptor alpha polypeptide (VNRA); Vitronectin receptor subunit alpha

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Gene Aliases: 1110004F14Rik; 2610028E01Rik; CD51; D430040G12Rik; ITGAV; MSK8; VNRA; VTNR

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UniProt ID: (Human) P06756, (Mouse) P43406

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Entrez Gene ID: (Human) 3685, (Rat) 296456, (Mouse) 16410

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Function(s)
virus receptor activity opsonin binding fibronectin binding protease binding protein kinase C binding receptor binding integrin binding protein binding coreceptor activity fibroblast growth factor binding C-X3-C chemokine binding insulin-like growth factor I binding signaling receptor activity neuregulin binding metal ion binding transforming growth factor beta binding extracellular matrix binding extracellular matrix protein binding voltage-gated calcium channel activity peptide binding protein heterodimerization activity integrin
Process(es)
angiogenesis blood vessel development vasculogenesis formation of primary germ layer cell adhesion cell-matrix adhesion positive regulation of cytosolic calcium ion concentration integrin-mediated signaling pathway positive regulation of cell proliferation tissue development negative regulation of macrophage derived foam cell differentiation negative regulation of lipid storage negative regulation of low-density lipoprotein particle clearance cell migration positive regulation of cell migration cell-substrate adhesion negative regulation of lipid transport cell adhesion mediated by integrin positive regulation of osteoblast proliferation heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading wound healing, spreading of epidermal cells endodermal cell differentiation apolipoprotein A-I-mediated signaling pathway apoptotic cell clearance positive regulation of cell adhesion viral entry into host cell negative regulation of lipoprotein metabolic process regulation of phagocytosis negative chemotaxis positive regulation of small GTPase mediated signal transduction ERK1 and ERK2 cascade calcium ion transmembrane transport transforming growth factor beta production entry into host cell by a symbiont-containing vacuole extrinsic apoptotic signaling pathway in absence of ligand cell-cell adhesion positive regulation of intracellular signal transduction negative regulation of entry of bacterium into host cell negative regulation of extrinsic apoptotic signaling pathway cellular calcium ion homeostasis cell growth positive regulation of MAPK cascade negative regulation of low-density lipoprotein particle receptor biosynthetic process regulation of apoptotic cell clearance inflammatory response multicellular organism development fertilization cell differentiation detection of molecule of bacterial origin regulation of ion transmembrane transport gonad morphogenesis T cell activation endothelial cell migration regulation of bone resorption focal adhesion assembly release of sequestered calcium ion into cytosol trophoblast giant cell differentiation response to nitric oxide
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