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Invitrogen
4EBP1 Recombinant Rabbit Monoclonal Antibody (JJ09-25)
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Product Details
MA5-32481
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JJ09-25
Immunogen
Synthetic peptide with Human eIF4EBP1 aa 1-49.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E, which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4E-BP1; eIF4E-binding protein 1; EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; MGC431; MGC4316; P/OKCL.6; PHAS-1; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1; unnamed protein product
Gene Aliases: 4E-BP1; 4EBP1; AA959816; BP-1; EIF4EBP1; PHAS-I
UniProt ID: (Human) Q13541, (Mouse) Q60876, (Rat) Q62622
Entrez Gene ID: (Human) 1978, (Mouse) 13685, (Rat) 116636
G1/S transition of mitotic cell cycle
regulation of translation
negative regulation of translation
TOR signaling
positive regulation of mitotic cell cycle
negative regulation of translational initiation
IRES-dependent translational initiation
regulation of translational initiation
insulin receptor signaling pathway
negative regulation of protein complex assembly
response to ischemia
lung development
response to ethanol
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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