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Invitrogen

FOXP1 Recombinant Rabbit Monoclonal Antibody (JF1017)

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FOXP1 Recombinant Rabbit Monoclonal Antibody (JF1017)

Product Details

MA5-32523

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Flow Cytometry (Flow)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JF1017

Immunogen

Synthetic peptide within human FOXP1 aa 615-653.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809800

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ23741; Fork head related protein like B; fork head-related protein like B; Forkhead box protein P1; Forkhead box protein P1 (FOXP1); Forkhead-related transcription factor 1; FOXP1; Glutamine rich factor 1; glutamine-rich factor 1; Mac-1-regulated forkhead; MFH; MGC12942; MGC88572; MGC99551; unnamed protein product

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Gene Aliases: 12CC4; 3110052D19Rik; 4932443N09Rik; AI461938; AW494214; FOXP1; hFKH1B; HSPC215; MFH; QRF1

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UniProt ID: (Human) Q9H334, (Rat) Q498D1, (Mouse) P58462

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Entrez Gene ID: (Human) 27086, (Rat) 297480, (Mouse) 108655

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding identical protein binding sequence-specific DNA binding metal ion binding androgen receptor binding sequence-specific double-stranded DNA binding chromatin binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein homodimerization activity protein heterodimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development positive regulation of mesenchymal cell proliferation pre-B cell differentiation positive regulation of immunoglobulin production negative regulation of B cell apoptotic process regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter heart development skeletal muscle tissue development motor neuron axon guidance positive regulation of endothelial cell migration ventral spinal cord development osteoclast differentiation lung development response to lipopolysaccharide regulation of tumor necrosis factor production immunoglobulin V(D)J recombination chemokine (C-C motif) ligand 2 secretion osteoclast development macrophage activation monocyte activation endothelial cell activation sarcomere organization regulation of monocyte differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle cell proliferation smooth muscle tissue development positive regulation of epithelial cell proliferation regulation of interleukin-1 beta secretion regulation of inflammatory response cardiac muscle cell differentiation regulation of cardiac muscle cell proliferation negative regulation of androgen receptor signaling pathway lung secretory cell differentiation T follicular helper cell differentiation cardiovascular system development interleukin-21 secretion regulation of defense response to bacterium regulation of lung goblet cell differentiation negative regulation of lung goblet cell differentiation regulation of macrophage colony-stimulating factor production regulation of endothelial tube morphogenesis positive regulation of cardiac muscle cell differentiation regulation of interleukin-12 secretion regulation of transcription, DNA-templated cellular response to DNA damage stimulus regulation of gene expression negative regulation of gene expression striatum development forebrain development regulation of interleukin-1 beta production regulation of interleukin-12 production positive regulation of interleukin-21 production response to testosterone animal organ development positive regulation of B cell receptor signaling pathway negative regulation of cell growth involved in cardiac muscle cell development cellular response to tumor necrosis factor positive regulation of hydrogen peroxide-mediated programmed cell death regulation of chemokine (C-X-C motif) ligand 2 production transcription, DNA-templated anatomical structure morphogenesis embryo development
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