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Invitrogen

PGC1 alpha/beta Recombinant Rabbit Monoclonal Antibody (JF09-71)

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PGC1 alpha/beta Recombinant Rabbit Monoclonal Antibody (JF09-71)

Product Details

MA5-32563

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JF09-71

Immunogen

Synthetic peptide within human pgc1 alpha aa 755-798 and aa 269-323.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809840

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. Ectopic expression of this protein has been shown to lead to increased mitochondrial number and basal oxygen consumption.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ERR ligand 1; L-PGC-1alpha; Ligand effect modulator 6; ligand effect modulator-6; PERC; PERC-s; lacks one estrogen receptor interaction domain; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferative activated receptor, gamma, coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1 beta; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a; peroxisome proliferator-activated receptor gamma coactivator-1 alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; pgc-1 alpha; pgc-1 beta; PGC-1-alpha; PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC-1alpha; Pgc-1alphaa; PGC-1beta; PGC-1beta/ERRL1; PGC1beta-1a; PGC1beta-1b; PGC1beta-2a; PGC1beta-2b; PPAR gamma coactivator variant form; PPAR Gamma Coactivator-1; PPAR gamma coactivator-1beta protein; PPAR-gamma coactivator 1-alpha; PPAR-gamma coactivator 1-beta; PPARAGCIalpha; PPARAGCIbeta; PPARgamma coactivator 1 beta; PPARgamma coactivator 1alpha; PPARGC-1-alpha; PPARGC-1-beta; transcriptional coactivator; transcriptional coactivator; PGC-1; unnamed protein product

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Gene Aliases: 4631412G21Rik; A830037N07Rik; ENSMUSG00000079510; ERRL1; Gm11133; LEM6; PERC; PGC-1; PGC-1(alpha); PGC-1(beta); PGC-1alpha; PGC-1v; PGC1; PGC1A; PGC1B; PGC1beta; Pgco1; PPARGC1; PPARGC1A; PPARGC1B

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UniProt ID: (Human) Q9UBK2, (Human) Q86YN6, (Mouse) O70343, (Rat) Q9QYK2, (Rat) Q811R2, (Mouse) Q8VHJ7

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Entrez Gene ID: (Human) 10891, (Human) 133522, (Mouse) 19017, (Rat) 83516, (Rat) 291567, (Mouse) 170826

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Function(s)
nucleic acid binding DNA binding transcription cofactor activity transcription coactivator activity RNA binding protein binding ligand-dependent nuclear receptor binding chromatin DNA binding ubiquitin protein ligase binding sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding lncRNA binding DNA-binding transcription factor binding estrogen receptor binding AF-2 domain binding nucleotide binding RNA polymerase II transcription cofactor activity chromatin binding transcription factor binding ligand-dependent nuclear receptor transcription coactivator activity molecular_function receptor activator activity transcription cofactor
Process(es)
temperature homeostasis cellular glucose homeostasis response to dietary excess gluconeogenesis regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter mRNA processing mitochondrion organization digestion RNA splicing positive regulation of gene expression response to muscle activity fatty acid oxidation respiratory electron transport chain developmental process circadian regulation of gene expression cellular response to oxidative stress homeostatic process response to starvation regulation of circadian rhythm negative regulation of neuron apoptotic process cellular respiration positive regulation of gluconeogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation rhythmic process negative regulation of smooth muscle cell proliferation protein stabilization brown fat cell differentiation neuron apoptotic process adipose tissue development protein-containing complex assembly energy homeostasis positive regulation of cold-induced thermogenesis intracellular estrogen receptor signaling pathway positive regulation of osteoclast differentiation transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter positive regulation of mitochondrion organization negative regulation of smooth muscle cell migration positive regulation of cellular metabolic process negative regulation of glycolytic process positive regulation of smooth muscle cell proliferation positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of neuron death positive regulation of cellular respiration positive regulation of mitochondrial DNA metabolic process positive regulation of muscle tissue development negative regulation of receptor activity regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of energy homeostasis positive regulation of ATP biosynthetic process response to hypoxia galactose metabolic process androgen metabolic process response to cold response to organic cyclic compound response to activity response to nutrient levels response to statin response to drug response to leucine flavone metabolic process cellular response to nitrite cellular response to tumor necrosis factor cellular response to fatty acid cellular response to hypoxia response to epinephrine response to norepinephrine cellular response to thyroid hormone stimulus ossification transcription from mitochondrial promoter actin filament organization positive regulation of alkaline phosphatase activity cellular response to reactive oxygen species positive regulation of phosphorylation positive regulation of bone resorption negative regulation of transcription, DNA-templated response to glucocorticoid response to cAMP bone trabecula formation positive regulation of receptor activity
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