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Invitrogen
PCSK9 Monoclonal Antibody (2F1)
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Product Details
MA5-32843
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2F1
Immunogen
Recombinant protein with Human PCSK9 1-201.
Conjugate
Form
Liquid
Concentration
1.084 mg/mL
Amount
108.4 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% Glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: convertase subtilisin; convertase subtilisin/kexin type 9 preproprotein; hypercholesterolemia; NARC-1; neural apoptosis regulated convertase 1; Neural apoptosis-regulated convertase 1; OTTHUMP00000009833; PC9; Proprotein convertase 9; proprotein convertase PC9; Proprotein convertase subtilisin/kexin type 9; Subtilisin/kexin-like protease PC9; unnamed protein product
Gene Aliases: AI415265; AI747682; FH3; FHCL3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9; PCSK9; PSEC0052
UniProt ID: (Human) Q8NBP7, (Mouse) Q80W65
Entrez Gene ID: (Human) 255738, (Mouse) 100102
RNA binding
serine-type endopeptidase activity
protein binding
peptidase activity
serine-type peptidase activity
hydrolase activity
sodium channel inhibitor activity
low-density lipoprotein particle binding
receptor inhibitor activity
apolipoprotein binding
very-low-density lipoprotein particle binding
apolipoprotein receptor binding
low-density lipoprotein particle receptor binding
very-low-density lipoprotein particle receptor binding
protein self-association
poly(A) RNA binding
serine protease
kidney development
liver development
negative regulation of receptor recycling
negative regulation of receptor internalization
positive regulation of receptor internalization
proteolysis
lipid metabolic process
triglyceride metabolic process
phospholipid metabolic process
apoptotic process
lysosomal transport
steroid metabolic process
cholesterol metabolic process
cellular response to starvation
negative regulation of low-density lipoprotein particle clearance
protein processing
protein autoprocessing
neurogenesis
neuron differentiation
low-density lipoprotein receptor particle metabolic process
low-density lipoprotein particle receptor catabolic process
regulation of low-density lipoprotein particle receptor catabolic process
positive regulation of low-density lipoprotein particle receptor catabolic process
cellular response to insulin stimulus
lipoprotein metabolic process
cholesterol homeostasis
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
negative regulation of sodium ion import across plasma membrane
negative regulation of receptor-mediated endocytosis involved in cholesterol transport
regulation of receptor activity
negative regulation of receptor activity
negative regulation of sodium ion transmembrane transporter activity
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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