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Invitrogen
TNN Monoclonal Antibody (BC-24)
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Product Details
MA5-32994
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
BC-24
Immunogen
Human tenascin.
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Amount
100 µg
Storage buffer
ascites/1.2% sodium acetate with 2mg BSA
Contains
0.01mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 1 mL of PBS buffer to yield a concentration of 100 µg/mL.
Positive Control - IHC: Human Mammary Cancer Tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants. During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Tenascin-N; Tenascin-W; TN-N; TN-W; unnamed protein product
Gene Aliases: TN-W; TNN; TNW
UniProt ID: (Human) Q9UQP3
Entrez Gene ID: (Human) 63923
cell-matrix adhesion
axonogenesis
positive regulation of neuron projection development
regulation of cell adhesion
regulation of cell migration
dendrite self-avoidance
regulation of bone development
positive regulation of sprouting angiogenesis
regulation of smooth muscle tissue development
neuron projection extension
regulation of multicellular organismal development
negative regulation of neuron migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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