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Invitrogen
Cytochrome P450 Reductase Recombinant Rabbit Monoclonal Antibody (JB54-31)
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FIGURE: 1 / 9
Cytochrome P450 Reductase Antibody (MA5-34675) in ICC/IF
Immunofluorescent analysis of Cytochrome P450 Reductase in HepG2 cells (green). Samples were fixed in paraformaldehyde and permeabilised with 0.25% Triton X100/PBS, incubated with Cytochrome P450 Reductase monoclonal antibody (Product # MA5-34675), followed by DAPI (blue).
Product Details
MA5-34675
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JB54-31
Immunogen
Recombinant protein within Human Cytochrome P450 Reductase aa 80-220.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: SK-Br-3, A549, mouse lung tissue lysate, rat brain tissue, human lung cancer tissue, human liver tissue, mouse testis tissue, HepG2.
Target Information
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCR; CPR; CY DKFZp686G04235; DKFZp686G04235; FLJ26468; NADPH Cytochrome; NADPH--cytochrome P450 reductase; NADPH--hemoprotein reductase; NADPH-dependent cytochrome P450 reductase; P450 (cytochrome) oxidoreductase; P450 Reductase; unnamed protein product
Gene Aliases: CPR; CYPOR; P450R; POR
UniProt ID: (Human) P16435
Entrez Gene ID: (Human) 5447
NADPH-hemoprotein reductase activity
cytochrome-b5 reductase activity, acting on NAD(P)H
protein binding
enzyme activator activity
nitric oxide dioxygenase activity
electron carrier activity
FMN binding
oxidoreductase activity
hydrolase activity
enzyme binding
iron-cytochrome-c reductase activity
flavin adenine dinucleotide binding
NADP binding
xenobiotic metabolic process
nitric oxide biosynthetic process
response to nutrient
response to xenobiotic stimulus
carnitine metabolic process
response to hormone
flavonoid metabolic process
fatty acid oxidation
electron transport chain
positive regulation of chondrocyte differentiation
negative regulation of apoptotic process
nitrate catabolic process
positive regulation of smoothened signaling pathway
nitric oxide catabolic process
positive regulation of growth plate cartilage chondrocyte proliferation
demethylation
cellular response to gonadotropin stimulus
cellular response to follicle-stimulating hormone stimulus
cellular response to peptide hormone stimulus
response to dexamethasone
positive regulation of steroid hormone biosynthetic process
cellular organofluorine metabolic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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