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Invitrogen
TYROBP Recombinant Rabbit Monoclonal Antibody (JG38-70)
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FIGURE: 1 / 7
TYROBP Antibody (MA5-34787) in ICC/IF
Immunofluorescence analysis of TYROBP is performed using THP-1 cells and THP1 differentiated to Macrophages. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with TYROBP Recombinant Rabbit Monoclonal Antibody (JG38-70) (Product # MA5-34787) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary ... View More
Product Details
MA5-34787
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JG38-70
Immunogen
Recombinant protein within Human DAP12 aa 1-113.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: THP-1, K562, human lung cancer tissue.
Target Information
DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells. DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction. Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice, as well as presenile dementia and bone cysts in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNAX adaptor protein 12; DNAX-activation protein 12; KAR-associated protein; Killer-activating receptor-associated protein; membrane protein; polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy; TYRO protein tyrosine kinase binding protein; TYRO protein tyrosine kinase-binding protein; TYROBP; unnamed protein product
Gene Aliases: DAP12; KARAP; PLOSL; PLOSL1; TYROBP
UniProt ID: (Human) O43914
Entrez Gene ID: (Human) 7305
negative regulation of cytokine production
stimulatory killer cell immunoglobulin-like receptor signaling pathway
stimulatory C-type lectin receptor signaling pathway
natural killer cell mediated immunity
immune effector process
myeloid leukocyte activation
macrophage activation involved in immune response
microglial cell activation involved in immune response
neutrophil activation involved in immune response
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
immune system process
positive regulation of immune system process
defense response
immune response
cellular defense response
signal transduction
cell surface receptor signaling pathway
integrin-mediated signaling pathway
positive regulation of gene expression
actin cytoskeleton organization
osteoclast differentiation
negative regulation of B cell proliferation
forebrain development
negative regulation of type I interferon production
positive regulation of type I interferon production
negative regulation of interleukin-10 production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of natural killer cell activation
negative regulation of transforming growth factor beta1 production
positive regulation of superoxide anion generation
positive regulation of macrophage fusion
intracellular signal transduction
apoptotic cell clearance
response to axon injury
protein stabilization
regulation of biological quality
semaphorin-plexin signaling pathway
beta-amyloid clearance
negative regulation of long-term synaptic potentiation
positive regulation of receptor localization to synapse
positive regulation of microglial cell mediated cytotoxicity
cellular response to beta-amyloid
positive regulation of protein localization to cell surface
regulation of osteoclast development
positive regulation of osteoclast development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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