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Invitrogen
IFNAR1 Recombinant Rabbit Monoclonal Antibody (6N3L3)
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FIGURE: 1 / 2
IFNAR1 Antibody (MA5-35051) in WB
Western blot analysis of IFNAR1 in extracts of various cell lines. Samples were incubated with IFNAR1 Monoclonal antibody (Product # MA5-35051) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3 min.
Product Details
MA5-35051
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rabbit
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
6N3L3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 458-557 of human IFNAR1 (P17181)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KVFLRCINYV FFPSLKPSSS IDEYFSEQPL KNLLLSTSEE QIEKCFIIEN ISTIATVEET NQTDEDHKKY SSQTSQDSGN YSNEDESESK TSEELQQDFV
Target Information
Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron,2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-& Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha-type antiviral protein; beta-type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; H3K1; IFN R1; IFN-alpha/beta receptor 1; IFN-alpha/betaR; IFN-alpha/betaR1; IFN-alpha/betaRalpha; IFN-R-1; IFNalpha/beta R1; IFNalpha/beta receptor 1; IFNalpha/beta-Ralpha; IFNalpha/betaR1; IFNR1; INF-a receptor; interferon (alpha and beta) receptor 1; interferon (alpha, beta and omega) receptor 1; Interferon alpha/beta receptor 1; interferon receptor 1; interferon-alpha receptor precursor; interferon-alpha/beta receptor 1; interferon-alpha/beta receptor alpha chain; interferon-beta receptor 1; Type I interferon receptor 1; unnamed protein product
Gene Aliases: AVP; CD118; Ifar; IFN-alpha-REC; IFNAR; IFNAR1; IFNBR; IFRC; IMD106; Infar
UniProt ID: (Human) P17181, (Mouse) P33896
Entrez Gene ID: (Human) 3454, (Rat) 288264, (Mouse) 15975
regulation of transcription from RNA polymerase II promoter
JAK-STAT cascade
response to virus
positive regulation of metabolic process
cytokine-mediated signaling pathway
response to lipopolysaccharide
cellular response to interferon-alpha
cellular response to interferon-beta
regulation of JAK-STAT cascade
type I interferon signaling pathway
cellular response to virus
positive regulation of protein localization to nucleus
positive regulation of cellular respiration
biological_process
positive regulation of interferon-gamma production
T cell activation
type I interferon biosynthetic process
positive regulation of interleukin-1 beta secretion
regulation of peptidyl-tyrosine phosphorylation
defense response to virus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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