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Invitrogen

RACK1 Recombinant Rabbit Monoclonal Antibody (7B6J4)

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View all (19) RACK1 antibodies

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Product Details

MA5-35405

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:6,000
-

Immunocytochemistry (ICC/IF)

1:100
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

7B6J4

Immunogen

Recombinant protein (or fragment)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Amount

25 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849306

Target Information

RACK1 (receptor for activated C kinase 1) was identified through its binding to various PKC isoforms. Its main function is to recruit PKC and various other proteins to specific locations to form multiprotein complexes, mediating various signal pathways. RACK1 is required for VANGL2 membrane localization and for PTK2/FAK1 phosphorylation and dephosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 12-3; activated protein kinase C receptor; Cell proliferation-inducing gene 21 protein; GNB2L1; guanine nucleotide binding protein (G protein) beta polypeptide 2-like 1; guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 sequence 1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide binding protein beta polypeptide 2-like 1; guanine nucleotide binding protein related; guanine nucleotide binding protein, beta 2, related sequence 1; guanine nucleotide binding protein, beta polypeptide 2-like 1; guanine nucleotide binding protein, beta-2, related sequence 1; Guanine nucleotide-binding protein subunit beta-2-like 1; Guanine nucleotide-binding protein subunit beta-like protein 12.3; HLC-7; Human lung cancer oncogene 7 protein; lung cancer oncogene 7; OTTHUMP00000223870; OTTHUMP00000223891; OTTHUMP00000223893; OTTHUMP00000223900; OTTHUMP00000223901; OTTHUMP00000223902; OTTHUMP00000223930; OTTHUMP00000223931; p205; PIG21; proliferation-inducing gene 21; protein homologous to chicken B complex protein, guanine nucleotide binding; protein kinase C receptor; rack-1; Receptor for activated C kinase; Receptor for activated C kinase 1; receptor for activated protein kinase C; Receptor of activated protein C kinase 1; Receptor of activated protein kinase C 1; Small ribosomal subunit protein RACK1; unnamed protein product

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Gene Aliases: AL033335; GB-like; Gnb2-rs1; GNB2L1; H12.3; HLC-7; HLC7; p205; PIG21; RACK1

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UniProt ID: (Rat) P63245, (Mouse) P68040, (Human) P63244

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Entrez Gene ID: (Rat) 83427, (Mouse) 14694, (Human) 10399

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Function(s)
protein kinase C binding ion channel inhibitor activity cysteine-type endopeptidase activator activity involved in apoptotic process enzyme binding protein phosphatase binding protein tyrosine kinase inhibitor activity receptor tyrosine kinase binding SH2 domain binding protein homodimerization activity poly(A) RNA binding receptor activity protein binding signaling adaptor activity RNA binding receptor binding enzyme activator activity protein serine/threonine kinase inhibitor activity cyclin binding identical protein binding ribosome binding translation regulator activity cadherin binding BH3 domain binding binding, bridging
Process(es)
osteoblast differentiation positive regulation of protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process protein kinase C-activating G-protein coupled receptor signaling pathway gastrulation negative regulation of gene expression negative regulation of translation negative regulation of Wnt signaling pathway negative regulation of cell growth positive regulation of cell migration positive regulation of cAMP catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein homooligomerization regulation of protein localization positive regulation of apoptotic process positive regulation of GTPase activity rhythmic process negative regulation of phagocytosis regulation of cell division positive regulation of cyclic-nucleotide phosphodiesterase activity regulation of cell cycle negative regulation of protein kinase B signaling positive regulation of mitochondrial depolarization negative regulation of protein tyrosine kinase activity regulation of establishment of protein localization to plasma membrane negative regulation of hydrogen peroxide-induced neuron death regulation of establishment of cell polarity positive regulation of gastrulation positive regulation of intrinsic apoptotic signaling pathway regulation of translation apoptotic process cell cycle multicellular organism development protein localization negative regulation of peptidyl-serine phosphorylation intracellular signal transduction regulation of growth cellular response to glucose stimulus cytoplasmic translation translation protein ubiquitination positive regulation of protein complex assembly negative regulation of protein binding positive regulation of Golgi to plasma membrane protein transport pigmentation negative regulation of smoothened signaling pathway cellular response to growth factor stimulus rescue of stalled ribosome regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway negative regulation of endoplasmic reticulum unfolded protein response negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide negative regulation of translational frameshifting
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