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Invitrogen
Thioredoxin 2 Recombinant Rabbit Monoclonal Antibody (9V7J1)
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Product Details
MA5-35514
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
9V7J1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 67-166 of human TXN2 (Q99757)
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Amount
80 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GPDFQDRVVN SETPVVVDFH AQWCGPCKIL GPRLEKMVAK QHGKVVMAKV DIDDHTDLAI EYEVSAVPTV LAMKNGDVVD KFVGIKDEDQ LEAFLKKLIG
Target Information
Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cystein residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and a number of transcription factors such as p53, NF-kB and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mitochondrial thioredoxin; mt-Trx; MTRX; mtTrx; Trx2; thioredoxin nuclear gene encoding mitochondrial protein; Thioredoxin, mitochondrial; Thioredoxin-2; Thioredoxin2; TRX-2; TRX2; TXN2; unnamed protein product
Gene Aliases: 2510006J11Rik; AI788873; COXPD29; MT-TRX; MTRX; TRX2; TXN; TXN2
UniProt ID: (Human) Q99757, (Mouse) P97493, (Rat) P97615
Entrez Gene ID: (Human) 25828, (Mouse) 56551, (Rat) 79462
cell redox homeostasis
sulfate assimilation
protein folding
glycerol ether metabolic process
transport
cellular response to oxidative stress
oxidation-reduction process
response to hypoxia
response to oxidative stress
response to nutrient
response to hormone
response to glucose
response to organic cyclic compound
cellular response to nutrient levels
response to drug
response to axon injury
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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