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Invitrogen

VCP Recombinant Rabbit Monoclonal Antibody (5H12)

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VCP Recombinant Rabbit Monoclonal Antibody (5H12)

Product Details

MA5-38305

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:20-1:200
-

Immunoprecipitation (IP)

1:200-1:1,000
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

5H12

Immunogen

A synthesized peptide derived from human VCP
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Amount

33 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol, 150mM NaCl

Contains

0.02% sodium azide

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898220

Product Specific Information

This antibody has been tested in direct-ELISA

Target Information

The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 15S Mg(2+)-ATPase p97 subunit; or HEL-S-70; p97 atpase; TER ATPase; Transitional endoplasmic reticulum ATPase; unnamed protein product; Valosin-containing protein; VCP

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Gene Aliases: CDC48; FTDALS6; HEL-220; HEL-S-70; p97; TERA; VCP

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UniProt ID: (Human) P55072, (Rat) P46462

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Entrez Gene ID: (Human) 7415, (Rat) 116643

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Function(s)
nucleotide binding RNA binding protein binding ATP binding lipid binding hydrolase activity ATPase activity protein phosphatase binding protein domain specific binding polyubiquitin binding ubiquitin protein ligase binding deubiquitinase activator activity K48-linked polyubiquitin binding MHC class I protein binding identical protein binding ADP binding ubiquitin-like protein ligase binding macromolecular complex binding ubiquitin-dependent protein binding BAT3 complex binding ubiquitin-specific protease binding receptor binding protein complex binding poly(A) RNA binding
Process(es)
DNA repair double-strand break repair ubiquitin-dependent protein catabolic process ER to Golgi vesicle-mediated transport autophagy cellular response to DNA damage stimulus I-kappaB kinase/NF-kappaB signaling proteasomal protein catabolic process positive regulation of mitochondrial membrane potential macroautophagy protein ubiquitination viral genome replication NAD metabolic process translesion synthesis endoplasmic reticulum unfolded protein response retrograde protein transport, ER to cytosol positive regulation of protein complex assembly positive regulation of proteasomal ubiquitin-dependent protein catabolic process endosome to lysosome transport via multivesicular body sorting pathway cellular response to heat negative regulation of hippo signaling stress granule disassembly interstrand cross-link repair ERAD pathway regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process establishment of protein localization positive regulation of protein catabolic process negative regulation of smoothened signaling pathway ATP metabolic process regulation of synapse organization mitotic spindle disassembly endoplasmic reticulum stress-induced pre-emptive quality control aggresome assembly cellular response to misfolded protein flavin adenine dinucleotide catabolic process positive regulation of canonical Wnt signaling pathway autophagosome maturation protein-DNA covalent cross-linking repair negative regulation of protein localization to chromatin cytoplasm protein quality control positive regulation of NIK/NF-kappaB signaling positive regulation of protein K63-linked deubiquitination regulation of aerobic respiration cellular response to arsenite ion positive regulation of oxidative phosphorylation regulation of protein localization to chromatin positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of ATP biosynthetic process activation of cysteine-type endopeptidase activity involved in apoptotic process protein N-linked glycosylation via asparagine ER-associated ubiquitin-dependent protein catabolic process protein hexamerization protein homooligomerization positive regulation of Lys63-specific deubiquitinase activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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