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Invitrogen

HDAC4 Monoclonal Antibody (7E2E6)

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HDAC4 Monoclonal Antibody (7E2E6)

Product Details

MA5-38538

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:200-1:1,000
-

Flow Cytometry (Flow)

1:200-1:400
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

7E2E6

Immunogen

Purified recombinant fragment of human HDAC4 (aa: 456-592) expressed in E. Coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898450

Product Specific Information

This antibody has been tested in indirect ELISA.

Target Information

Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp779K1053; HD4; HD7; HD7b; HD9; HDAC; HDAC4; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; Histone deacetylase 4; histone deacetylase A; KIAA0744; MITR; unnamed protein product

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Gene Aliases: 4932408F19Rik; AHO3; AI047285; BDMR; HA6116; HD4; HDAC-4; HDAC-A; HDAC4; HDACA; KIAA0288; NEDCHF; NEDCHID

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UniProt ID: (Human) P56524, (Mouse) Q6NZM9

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Entrez Gene ID: (Human) 9759, (Mouse) 208727

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding histone deacetylase activity protein binding zinc ion binding hydrolase activity SUMO transferase activity potassium ion binding protein deacetylase activity histone binding identical protein binding histone deacetylase binding metal ion binding binding, bridging RNA polymerase II sequence-specific DNA binding transcription factor binding DNA-binding transcription factor binding histone deacetylase activity, hydrolytic mechanism RNA polymerase III transcription factor binding core promoter binding DNA binding chromatin binding transcription corepressor activity transcription factor binding protein kinase binding histone deacetylase activity (H3-K14 specific) NAD-dependent histone deacetylase activity (H3-K14 specific) histone deacetylase activity (H3-K9 specific) activating transcription factor binding histone deacetylase activity (H4-K16 specific) sequence-specific DNA binding transcription regulatory region DNA binding NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) repressing transcription factor binding NAD-dependent histone deacetylase activity (H3-K18 specific) histone modifying enzyme
Process(es)
negative regulation of transcription from RNA polymerase II promoter chromatin organization chromatin remodeling protein deacetylation inflammatory response nervous system development positive regulation of cell proliferation negative regulation of macromolecule biosynthetic process negative regulation of myotube differentiation negative regulation of transcription by competitive promoter binding response to denervation involved in regulation of muscle adaptation cardiac muscle hypertrophy in response to stress protein sumoylation B cell differentiation positive regulation of protein sumoylation regulation of gene expression, epigenetic B cell activation negative regulation of gene expression, epigenetic negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter type I interferon signaling pathway response to interleukin-1 skeletal system development osteoblast development transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of cell proliferation positive regulation of lamellipodium assembly regulation of cardiac muscle contraction by calcium ion signaling positive regulation of smooth muscle cell migration chromatin modification histone deacetylation peptidyl-lysine deacetylation response to drug regulation of protein binding negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of neuron apoptotic process negative regulation of osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of smooth muscle cell proliferation regulation of skeletal muscle fiber development positive regulation of sequence-specific DNA binding transcription factor activity regulation of striated muscle cell differentiation histone H3 deacetylation histone H4 deacetylation positive regulation of reactive oxygen species biosynthetic process
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