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Invitrogen
TLR9 Monoclonal Antibody (1B12H2)
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FIGURE: 1 / 6
TLR9 Antibody (MA5-38645) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of TLR9 in SK-OV-3 cells using TLR9 Monoclonal Antibody (Product # MA5-38645) (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Product # 35503)
Product Details
MA5-38645
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1B12H2
Immunogen
Purified recombinant fragment of human TLR9 (aa: 868-1016) expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
The protein encoded by this gene is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD289; orphan receptor; Toll-like receptor 9; unspliced isoform
Gene Aliases: CD289; TLR9; UNQ5798/PRO19605
UniProt ID: (Human) Q9NR96
Entrez Gene ID: (Human) 54106
microglial cell activation
positive regulation of cytokine production
activation of innate immune response
toll-like receptor signaling pathway
immune system process
positive regulation of immunoglobulin production
regulation of dendritic cell cytokine production
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
immune response
signal transduction
I-kappaB kinase/NF-kappaB signaling
male gonad development
response to virus
positive regulation of autophagy
positive regulation of gene expression
maintenance of gastrointestinal epithelium
positive regulation of B cell proliferation
positive regulation of type I interferon production
detection of molecule of bacterial origin
positive regulation of chemokine production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-18 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
toll-like receptor 9 signaling pathway
positive regulation of toll-like receptor 9 signaling pathway
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
innate immune response
regulation of B cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
regulation of inflammatory response
positive regulation of inflammatory response
defense response to Gram-negative bacterium
regulation of B cell activation
positive regulation of B cell activation
defense response to virus
negative regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
cellular response to metal ion
defense response to other organism
endolysosomal toll-like receptor signaling pathway
negative regulation of calcium-transporting ATPase activity
cellular response to chloroquine
positive regulation of intestinal epithelial cell development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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