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Invitrogen
GTF2I Recombinant Rabbit Monoclonal Antibody (JE56-20)
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FIGURE: 1 / 11
GTF2I Antibody (MA5-42491) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded human stomach carcinoma tissue using GTF2I Recombinant Monoclonal Antibody (Product # MA5-42491). The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the GTF2I ant... View More
Product Details
MA5-42491
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE56-20
Immunogen
Synthetic peptide within N-terminal Human TFII I.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: A431 cell lysate, Jurkat cell lysate, Hela cell lysate, MCF-7 cell lysate, PC-12 cell lysate, rat kidney tissue, human tonsil tissue, human thyroid tissue, human colon carcinoma tissue, human skin tissue, human spleen tissue, human breast carcinoma tissue, human stomach carcinoma tissue, human small intestine tissue, human pancreas tissue.
Subcellular Location: Nucleus, Cytoplasm.
Target Information
This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11. 23. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7, 13 and 21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BAP-135; Bruton tyrosine kinase-associated protein 135; BTK-associated protein, 135kD; General transcription factor II-I; GTFII-I; Mutations: 192:OK; OTTHUMP00000209509; protein kinase substrate; SPIN; SRF-Phox1-interacting protein; TFII-I; tfiii; unnamed protein product; Williams-Beuren syndrome chromosomal region 6 protein; Williams-Beuren syndrome chromosome region 6
Gene Aliases: BAP135; BTKAP1; DIWS; GTF2I; Gtf2ird1; GTFII-I; IB291; SPIN; TFII-I; WBS; WBSCR6
UniProt ID: (Human) P78347, (Rat) Q5U2Y1
Entrez Gene ID: (Human) 2969, (Rat) 353256
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
molecular_function
mitogen-activated protein kinase binding
general transcription factor
transcription from RNA polymerase II promoter
negative regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transition between slow and fast fiber
negative regulation of cytosolic calcium ion concentration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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