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Invitrogen
IL4R Recombinant Rabbit Monoclonal Antibody (R001)
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Product Details
MA5-43118
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
R001
Immunogen
Recombinant Human IL-4R/CD124 protein (1-232).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
200 µg
Purification
Protein A
Storage buffer
arginine/histidine with 0.02% Tween 80, 120mM NaCl
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Specificity: Human IL-4R/CD124
Target Information
IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor which binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine and mucus production at sites of allergic inflammmation. The IL4 response is involved in promoting Th2 differentiation. The secreted extracellular domain of IL4R alpha, called sIL4R alpha, can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. It has no signaling abilities. Allelic variations in the IL4RA gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD124; il-4 receptor; IL-4 receptor subunit alpha; IL4Ra; interleukin 13 receptor; interleukin-4 receptor alpha chain; Interleukin-4 receptor subunit alpha; unnamed protein product
Gene Aliases: 582J2.1; CD124; IL-4RA; IL4R; IL4RA
UniProt ID: (Human) P24394
Entrez Gene ID: (Human) 3566
immune system process
production of molecular mediator involved in inflammatory response
positive regulation of immunoglobulin production
immune response
signal transduction
immunoglobulin mediated immune response
cytokine-mediated signaling pathway
positive regulation of chemokine production
interleukin-4-mediated signaling pathway
defense response to protozoan
positive regulation of macrophage activation
positive regulation of mast cell degranulation
T-helper 1 cell differentiation
T-helper 2 cell differentiation
negative regulation of T-helper 1 cell differentiation
positive regulation of T-helper 2 cell differentiation
positive regulation of cold-induced thermogenesis
positive regulation of myoblast fusion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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