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Invitrogen

alpha Synuclein Monoclonal Antibody (4F1), FITC

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alpha Synuclein Monoclonal Antibody (4F1), FITC

Product Details

MA5-45847

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

1:200
-

Immunocytochemistry (ICC/IF)

1:100
-

ELISA (ELISA)

1:1,000
-

Dot blot (DB)

1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

4F1

Immunogen

Mouse alpha synuclein aggregate
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

9.1mM sodium bicarbonate/PBS, pH 7.4, with 640.91mM DMSO, 136.36mM ethanolamine

Contains

no preservative

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932301

Product Specific Information

A 1:1,000 dilution of MA5-45847 was sufficient for detection of Alpha Synuclein in 15 µg of human brain cell lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Binds multiple linear epitopes within human alpha synuclein: 21-70 aa, 61-90 aa, and 101-140 aa, determined using Dot blot and ELISA with corresponding peptides. Detects approximately 14 kDa band corresponding to Alpha synuclein. Band at approximately 40 kDa is a trimer.

Target Information

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 41 synuclein; Alpha synuclein; Alpha-synuclein; I+/--synuclein; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; SNCA; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor); unnamed protein product

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Gene Aliases: alphaSYN; NACP; PARK1; PARK4; PD1; SNCA; Syn

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UniProt ID: (Human) P37840, (Rat) P37377, (Mouse) O55042

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Entrez Gene ID: (Human) 6622, (Rat) 29219, (Mouse) 20617

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Function(s)
SNARE binding magnesium ion binding transcription regulatory region sequence-specific DNA binding actin binding enzyme inhibitor activity protein kinase inhibitor activity cysteine-type endopeptidase inhibitor activity fatty acid binding copper ion binding calcium ion binding protein binding phospholipid binding microtubule binding enzyme activator activity ferrous iron binding zinc ion binding lipid binding oxidoreductase activity kinesin binding enzyme binding protein domain specific binding Hsp70 protein binding histone binding identical protein binding alpha-tubulin binding phospholipase binding metal ion binding tau protein binding beta-tubulin binding phosphoprotein binding binding, bridging phospholipase D inhibitor activity dynein complex binding protein sequestering activity transporter regulator activity cuprous ion binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process dynein binding protein N-terminus binding arachidonic acid binding membrane trafficking regulatory protein
Process(es)
negative regulation of transcription from RNA polymerase II promoter microglial cell activation positive regulation of receptor recycling positive regulation of neurotransmitter secretion synaptic transmission, dopaminergic fatty acid metabolic process neutral lipid metabolic process phospholipid metabolic process glutathione metabolic process mitochondrial membrane organization chemical synaptic transmission neurotransmitter secretion adult locomotory behavior response to xenobiotic stimulus response to iron(II) ion negative regulation of platelet-derived growth factor receptor signaling pathway regulation of glutamate secretion regulation of dopamine secretion synaptic vesicle exocytosis synaptic vesicle priming negative regulation of microtubule polymerization receptor internalization protein destabilization response to magnesium ion response to lipopolysaccharide response to interferon-gamma cellular response to oxidative stress SNARE complex assembly positive regulation of SNARE complex assembly regulation of locomotion response to cocaine dopamine biosynthetic process dopamine metabolic process mitochondrial ATP synthesis coupled electron transport regulation of macrophage activation positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of neuron apoptotic process cellular response to fibroblast growth factor stimulus positive regulation of endocytosis negative regulation of exocytosis positive regulation of exocytosis negative regulation of dopamine metabolic process regulation of neurotransmitter secretion behavioral response to cocaine regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity synaptic vesicle endocytosis synaptic vesicle transport positive regulation of inflammatory response positive regulation of synaptic transmission synapse organization regulation of acyl-CoA biosynthetic process protein oligomerization protein tetramerization positive regulation of release of sequestered calcium ion into cytosol neuron apoptotic process dopamine uptake involved in synaptic transmission negative regulation of dopamine uptake involved in synaptic transmission negative regulation of serotonin uptake regulation of norepinephrine uptake negative regulation of norepinephrine uptake calcium ion homeostasis excitatory postsynaptic potential long-term synaptic potentiation positive regulation of inositol phosphate biosynthetic process membrane organization negative regulation of thrombin receptor signaling pathway regulation of microtubule cytoskeleton organization response to interleukin-1 cellular response to copper ion cellular response to epinephrine stimulus fibril organization negative regulation of mitochondrial electron transport, NADH to ubiquinone positive regulation of hydrogen peroxide catabolic process regulation of synaptic vesicle recycling regulation of reactive oxygen species biosynthetic process response to desipramine positive regulation of protein localization to cell periphery negative regulation of chaperone-mediated autophagy regulation of presynapse assembly amyloid fibril formation regulation of reactive oxygen species metabolic process negative regulation of protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process aging regulation of phospholipase activity negative regulation of transporter activity negative regulation of monooxygenase activity positive regulation of peptidyl-serine phosphorylation negative regulation of histone acetylation response to drug negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of neuron apoptotic process oxidation-reduction process positive regulation of protein serine/threonine kinase activity regulation of neuron death positive regulation of glutathione peroxidase activity
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