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Invitrogen

Glucocorticoid receptor (NR3C1) Recombinant Rabbit Monoclonal Antibody (HL1149)

View all (55) Glucocorticoid Receptor (Nr3c1) antibodies

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Product Details

MA5-46938

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL1149

Immunogen

Recombinant protein encompassing a sequence within the center region of human Glucocorticoid Receptor. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2938010

Product Specific Information

Store as concentrated solution.

Centrifuge briefly prior to opening vial.

Target Information

Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance. Studies have shown that glucocorticoid receptor (GR) must be associated with a complex of chaperone proteins for ligand activation. GR binds to known steroids such as dexamethasone with nanomolar affinity

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Glucocorticoid receptor; glucocorticoid receptor 1; GR; gr alpha; GR Kit; hGR DL-1; hGR NS-1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3 group C member 1 variant hGR-B(54); nuclear receptor subfamily 3 group C member 1 variant hGR-B(77); nuclear receptor subfamily 3 group C member 1 variant hGR-B(93); nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); OTTHUMP00000222854; OTTHUMP00000222858; putative upstream ORF.; Unknown; unnamed protein product

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Gene Aliases: GCCR; GCR; GCRST; GR; GRL; Grl-1; Grl1; NR3C1

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UniProt ID: (Human) P04150, (Mouse) P06537

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Entrez Gene ID: (Human) 2908, (Mouse) 14815

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding RNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding glucocorticoid receptor activity steroid binding protein binding zinc ion binding lipid binding TBP-class protein binding protein kinase binding estrogen response element binding identical protein binding sequence-specific DNA binding metal ion binding Hsp90 protein binding steroid hormone binding sequence-specific double-stranded DNA binding promoter-specific chromatin binding RNA polymerase II regulatory region DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding double-stranded DNA binding steroid hormone receptor activity transcription coactivator activity transcription factor binding Hsp70 protein binding receptor tyrosine kinase binding heat shock protein binding protein complex binding glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity hormone binding protein homodimerization activity protein heterodimerization activity protein dimerization activity
Process(es)
regulation of gluconeogenesis chromatin remodeling transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter glucocorticoid metabolic process regulation of glucose metabolic process positive regulation of glutamate secretion chromatin modification adrenal gland development negative regulation of synaptic plasticity regulation of glucocorticoid biosynthetic process regulation of cell proliferation maternal behavior glucocorticoid receptor signaling pathway negative regulation of vascular permeability steroid hormone mediated signaling pathway glucocorticoid mediated signaling pathway positive regulation of neuron apoptotic process positive regulation of transcription from RNA polymerase II promoter response to arsenic-containing substance chromatin-mediated maintenance of transcription mammary gland duct morphogenesis positive regulation of dendritic spine development positive regulation of cell growth involved in cardiac muscle cell development cellular response to steroid hormone stimulus cellular response to dexamethasone stimulus negative regulation of glucocorticoid mediated signaling pathway positive regulation of glucocorticoid receptor signaling pathway negative regulation of transcription from RNA polymerase II promoter chromatin organization regulation of transcription from RNA polymerase II promoter apoptotic process chromosome segregation signal transduction response to wounding gene expression microglia differentiation intracellular steroid hormone receptor signaling pathway nuclear receptor-mediated corticosteroid signaling pathway synaptic transmission, glutamatergic negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated astrocyte differentiation cell division response to glucocorticoid response to cortisol motor behavior cellular response to glucocorticoid stimulus cellular response to transforming growth factor beta stimulus neuroinflammatory response response to ketone positive regulation of pri-miRNA transcription from RNA polymerase II promoter
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