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Invitrogen
Aurora A Monoclonal Antibody (1A11)
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FIGURE: 1 / 2
Aurora A Antibody (MA5-47380) in ICC/IF
Immunofluorescent analysis of Aurora A in HeLa cell culture. Samples were stained with Aurora A monoclonal antibody (Product # MA5-47380) in green. Costained with chicken pAb to vimentin, in red. The blue is DAPI staining of nuclear DNA. The aurora A antibody labels aurora A protein expressed in spindle poles at late mitosis.
Product Details
MA5-47380
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A11
Immunogen
Full length recombinant human aurora A expressed in and purified from E. coli
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
cell culture media
Contains
5mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
AURKA (Aurora A) is a serine/threonine kinase that regulates mitosis by association in vivo with centrosomes. Overexpression of AURKA is observed in many types of cancer. Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment. Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARK-1; AURAK; Aurora 2; aurora A; Aurora A Kinase; aurora family kinase 1; Aurora kinase A; aurora-related kinase 1; aurora/IP; aurora/IPL1-like kinase; Aurora/IPL1-related kinase 1; AURORA2; Breast tumor-amplified kinase; EC 2.7.11.1; hARK1; Ipl1- and aurora-related kinase 1; IPL1-related kinase; MGC34538; OTTHUMP00000031341; OTTHUMP00000166072; protein phosphatase 1, regulatory subunit 47; RP5-1167H4.6; serine/threonine kinase 6; serine/threonine protein kinase 15; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase Ayk1; unnamed protein product
Gene Aliases: AIK; AIRK1; ARK-1; ARK1; AU019385; AURA; AURKA; Aurora-A; AW539821; AYK1; BTAK; IAK; IAK1; PPP1R47; STK15; STK6; STK7
UniProt ID: (Human) O14965, (Mouse) P97477
Entrez Gene ID: (Human) 6790, (Mouse) 20878
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein kinase binding
ubiquitin protein ligase binding
histone kinase activity (H3-S10 specific)
protein heterodimerization activity
protein serine kinase activity
molecular function activator activity
transferase activity, transferring phosphorus-containing groups
histone serine kinase activity
non-receptor serine/threonine protein kinase
G2/M transition of mitotic cell cycle
meiotic spindle organization
microtubule cytoskeleton organization
mitotic cell cycle
chromatin remodeling
protein phosphorylation
apoptotic process
spindle organization
mitotic spindle organization
spindle assembly involved in female meiosis I
centrosome cycle
mitotic centrosome separation
response to wounding
anterior/posterior axis specification
regulation of G2/M transition of mitotic cell cycle
negative regulation of gene expression
peptidyl-serine phosphorylation
cell projection organization
regulation of protein stability
negative regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cytokinesis
regulation of microtubule-based process
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
cell cycle G2/M phase transition
positive regulation of mitotic nuclear division
positive regulation of mitotic cell cycle
regulation of centrosome cycle
protein autophosphorylation
cell division
meiotic cell cycle
centrosome localization
cilium disassembly
protein localization to centrosome
positive regulation of cell cycle process
positive regulation of mitochondrial fission
liver regeneration
positive regulation of oocyte maturation
regulation of signal transduction by p53 class mediator
neuron projection extension
cell cycle
mitotic nuclear division
meiotic nuclear division
phosphorylation
histone-serine phosphorylation
centrosome organization
negative regulation of spindle checkpoint
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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