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Invitrogen

Aurora A/B Monoclonal Antibody (3H1)

View all (2) Aurora A/B antibodies

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Aurora A/B Monoclonal Antibody (3H1)

Product Details

MA5-47418

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

3H1

Immunogen

Full length recombinant human Aurora A protein expressed in and purified from E. coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS with 50% glycerol

Contains

5mM sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2942400

Target Information

The Aurora gene, a serine-threonine kinase, orginally discovered in Drosophila, has been found to be responsible for a chromosomal segregation defect. The mammalian homologues of Drosophila Aurora have been termed ARK1 (Aurora-related kinase 1) and ARK2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AIM-1; ARK-1; ARK-2; Aurora 1; Aurora 2; aurora A; aurora B; aurora family kinase 1; Aurora kinase A; Aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; Aurora- and IPL1-like midbody-associated protein 1; aurora- and Ipl1-like midbody-associated protein 1 homolog; aurora-1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; aurora/IPL1-like kinase; Aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; Breast tumor-amplified kinase; Ipl1- and aurora-related kinase 1; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase Ayk1; STK-1; unnamed protein product

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Gene Aliases: AIK; AIK2; AIM-1; AIM1; AIRK1; AIRK2; AL022959; ARK-1; ARK-2; ARK1; ARK2; AU019385; AURA; AurB; AURKA; AURKB; aurkb-sv1; aurkb-sv2; Aurora-A; AW539821; AYK1; BTAK; IAK; IAK1; IPL1; PPP1R47; PPP1R48; STK-1; STK1; STK12; STK15; STK5; STK6; STK7

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UniProt ID: (Human) O14965, (Human) Q96GD4, (Mouse) P97477, (Mouse) O70126, (Rat) O55099

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Entrez Gene ID: (Human) 6790, (Human) 9212, (Mouse) 20878, (Rat) 261730, (Mouse) 20877, (Rat) 114592

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding kinase activity transferase activity protein kinase binding ubiquitin protein ligase binding histone kinase activity (H3-S10 specific) protein heterodimerization activity protein serine kinase activity molecular function activator activity kinase binding transferase activity, transferring phosphorus-containing groups histone serine kinase activity metal ion binding non-receptor serine/threonine protein kinase
Process(es)
G2/M transition of mitotic cell cycle meiotic spindle organization microtubule cytoskeleton organization mitotic cell cycle chromatin remodeling protein phosphorylation apoptotic process spindle organization mitotic spindle organization spindle assembly involved in female meiosis I centrosome cycle mitotic centrosome separation response to wounding anterior/posterior axis specification regulation of G2/M transition of mitotic cell cycle negative regulation of gene expression peptidyl-serine phosphorylation cell projection organization regulation of protein stability negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of cytokinesis regulation of microtubule-based process negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process cell cycle G2/M phase transition positive regulation of mitotic nuclear division positive regulation of mitotic cell cycle regulation of centrosome cycle protein autophosphorylation cell division meiotic cell cycle centrosome localization cilium disassembly protein localization to centrosome positive regulation of cell cycle process positive regulation of mitochondrial fission liver regeneration positive regulation of oocyte maturation regulation of signal transduction by p53 class mediator neuron projection extension negative regulation of transcription from RNA polymerase II promoter mitotic cytokinesis negative regulation of B cell apoptotic process positive regulation of microtubule depolymerization positive regulation of telomere maintenance negative regulation of cytokinesis positive regulation of cytokinesis protein localization to kinetochore cellular response to UV cleavage furrow formation post-translational protein modification mitotic cytokinesis checkpoint negative regulation of innate immune response mitotic spindle midzone assembly attachment of mitotic spindle microtubules to kinetochore regulation of chromosome segregation midbody abscission positive regulation of mitotic sister chromatid segregation positive regulation of mitotic cell cycle spindle assembly checkpoint mitotic spindle assembly repair of mitotic kinetochore microtubule attachment defect cGAS/STING signaling pathway negative regulation of cGAS/STING signaling pathway positive regulation of mitotic sister chromatid separation positive regulation of attachment of mitotic spindle microtubules to kinetochore positive regulation of mitotic cytokinesis positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore mitotic sister chromatid biorientation cell cycle mitotic nuclear division meiotic nuclear division phosphorylation histone-serine phosphorylation centrosome organization negative regulation of spindle checkpoint response to estradiol spindle checkpoint histone H3-S28 phosphorylation aging cell proliferation abscission
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