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Invitrogen

CD100 (SEMA4D) Monoclonal Antibody (M188)

View all (41) CD100 (SEMA4D) antibodies

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Product Details

MA5-47680

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

M188

Immunogen

Clone (M188) was generated from a recombinant protein corresponding to the C-terminal region of human Semaphorin-4D.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Amount

25 µg

Purification

Protein G

Storage buffer

PBS with 1mg/mL BSA, 50% glycerol

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2942661

Product Specific Information

This antibody detects a 150 kDa* band on SDS-PAGE immunoblots of adult mouse brain.

Target Information

Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development. CD100 (also known as semaphorin 4d), a 150 kDa homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro. CD100 modifies CD40-CD40L B cell signaling by augmenting B cell aggregation and survival and down regulating CD23 expression. CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling. CD100 is expressed on resting and PHA stimulated T cells. The protein is weakly expressed on NK cells, EBV transformed B cells, monocytes and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A8; BB18; CD100; GR3; M-Sema G; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D; Sema J; semaphorin H; Semaphorin-4D; Semaphorin-C-like 2; Semaphorin-J; unnamed protein product

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Gene Aliases: A8; BB18; C9orf164; CD100; coll-4; COLL4; GR3; M-sema-G; SEMA4D; Semacl2; SEMAJ; Semcl2

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UniProt ID: (Human) Q92854, (Mouse) O09126

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Entrez Gene ID: (Human) 10507, (Rat) 306790, (Mouse) 20354

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Function(s)
transmembrane signaling receptor activity receptor binding protein binding semaphorin receptor binding signaling receptor activity neuropilin binding identical protein binding chemorepellent activity receptor agonist activity receptor activity membrane-bound signaling molecule intercellular signal molecule
Process(es)
negative regulation of transcription from RNA polymerase II promoter neural crest cell migration positive regulation of protein phosphorylation immune response cell adhesion negative regulation of cell adhesion nervous system development axonogenesis axon guidance regulation of cell shape cell differentiation positive regulation of cell migration regulation of cell projection organization positive regulation of Rho protein signal transduction negative regulation of apoptotic process positive regulation of GTPase activity ossification involved in bone maturation negative regulation of osteoblast differentiation positive regulation of collateral sprouting regulation of dendrite morphogenesis positive regulation of axonogenesis negative chemotaxis positive regulation of protein kinase B signaling regulation of synapse assembly bone trabecula morphogenesis regulation of biological quality leukocyte aggregation semaphorin-plexin signaling pathway positive regulation of intracellular signal transduction positive regulation of inhibitory synapse assembly multicellular organism development negative regulation of alkaline phosphatase activity positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of peptidyl-tyrosine phosphorylation negative regulation of peptidyl-tyrosine phosphorylation semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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