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CD49d (Integrin alpha 4) (Natalizumab Biosimilar) Recombinant Rabbit Monoclonal Antibody (Natalizumab)
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FIGURE: 1 / 1
CD49d (Integrin alpha 4) (Natalizumab Biosimilar) Antibody (MA5-48046) in Flow
Flow Cytometry analysis of Natalizumab in Human lymphocytes using CD49d (Integrin alpha 4) (Natalizumab Biosimilar) Monoclonal Antibody (Product # MA5-48046). Cells were stained with an isotype control, FITC Chimeric monoclonal antibody (Product # MA5-47752) (panel A), or CD49d (Integrin alpha 4) (Natalizumab Biosimilar) Monoclonal Antibody (panel B) at a concentration of 1 µg/mL for 30 mins at RT. After wa... View More
Product Details
MA5-48046
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
Natalizumab
Immunogen
The RAMOS cell line, a non-EBV releasing cell line, injected into mice.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
200 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Specificity: This antibody binds to the alpha 4 binds subunit of alpha-4Beta1 (also known as very late antigen 4 [VLA-4] or CD49d-CD29) and alpha-4Beta7 integrin
MA5-48046 is a chimeric antibody. The variable regions from one species have been grafted to the backbone of the other species.
Target Information
The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49d; Integrin alpha-4; Integrin alpha-IV; ITGA-IV; unnamed protein product; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 subunit alpha
Gene Aliases: CD49D; IA4; ITGA4
UniProt ID: (Human) P13612
Entrez Gene ID: (Human) 3676
immune response in gut-associated lymphoid tissue
positive regulation of leukocyte migration
cell-matrix adhesion involved in ameboidal cell migration
cell adhesion
leukocyte cell-cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
tissue development
B cell differentiation
cell-cell adhesion mediated by integrin
heterotypic cell-cell adhesion
substrate adhesion-dependent cell spreading
endodermal cell differentiation
receptor clustering
negative regulation of vasoconstriction
embryonic morphogenesis
leukocyte migration
leukocyte tethering or rolling
diapedesis
axonogenesis involved in innervation
cellular response to cytokine stimulus
negative regulation of protein homodimerization activity
cell-cell adhesion
import into cell
positive regulation of leukocyte cell-cell adhesion
positive regulation of leukocyte tethering or rolling
cellular response to beta-amyloid
positive regulation of vascular endothelial cell proliferation
neuron projection extension
clathrin-mediated extracellular exosome endocytosis
positive regulation of endothelial cell apoptotic process
positive regulation of T cell migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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