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Invitrogen
CD147 Recombinant Mouse Monoclonal Antibody (11F3)
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FIGURE: 1 / 9
CD147 Antibody (MA5-50094) in ICC/IF
Immunocytochemistry analysis of HeLa cells with CD147 monoclonal antibody (Product # MA5-50094) at 1:150, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG (H+L).
Product Details
MA5-50094
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
11F3
Immunogen
Recombinant Human CD147 protein
Conjugate
Form
Liquid
Concentration
0.65 mg/mL
Amount
65 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% Proclin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CD147 (basigin, neurothelin, OX-47, 5A11, CE9, M6, EMMPRIN, extracellular matrix metalloproteinase inducer, TCSF, tumour cell-derived collagenase-stimulatory factor) is a 50-60 kDa glycoprotein with multiple glycosylated forms. CD147 is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. CD147 is also a member of the immunoglobulin superfamily. The highest level of CD147 expression is on metabolically active cells, such as lymphoblasts, inflammatory cells, brown adipocytes and malignant tumor cells. CD147 has multiple functions, including facilitating of cell surface expression of monocarboxylate transporter proteins and extracellular matrix metalloproteinases, regulation of integrin functions, it plays roles in cell development and activation, fetal development or retinal function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5F7; adhesion molecule; amino acid feature: intracellular domain, aa 707 .. 829; amino acid feature: transmembrane domain, aa 638 .. 706; amino acid feature: extracellular domain, aa 86 .. 637; Basigin; CD147; Collagenase stimulatory factor; EMMPRIN; Extracellular matrix metalloproteinase inducer; HAb18G; Hepatoma-associated antigen; Leukocyte activation antigen M6; OK blood group antigen; retinal glycoprotein; TCSF; Tumor cell-derived collagenase stimulatory factor; unnamed protein product
Gene Aliases: 5F7; BSG; CD147; EMMPRIN; EMPRIN; HAb18G; OK; TCSF; UNQ6505/PRO21383
UniProt ID: (Human) P35613
Entrez Gene ID: (Human) 682
angiogenesis
neural retina development
homophilic cell adhesion via plasma membrane adhesion molecules
cell surface receptor signaling pathway
axon guidance
embryo implantation
positive regulation of vascular endothelial growth factor production
positive regulation of endothelial cell migration
neutrophil chemotaxis
positive regulation of interleukin-6 production
odontogenesis of dentin-containing tooth
response to peptide hormone
photoreceptor cell maintenance
positive regulation of viral entry into host cell
response to mercury ion
decidualization
viral entry into host cell
response to cAMP
endothelial tube morphogenesis
dendrite self-avoidance
protein localization to plasma membrane
positive regulation of matrix metallopeptidase secretion
neuron projection extension
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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