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Invitrogen

FGFR1 Recombinant Rabbit Monoclonal Antibody (10A9)

View all (67) FGFR1 antibodies

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Product Details

MA5-50230

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

1:20-1:200
-

Flow Cytometry (Flow)

1:20-1:200
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

10A9

Immunogen

Recombinant Human FGFR1 protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.93 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.03% Proclin 300

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3092451

Target Information

FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). The FGF Receptor family plays an important role in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth. FGFR1 is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body. Other defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, Antley-Bixler syndrome. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 2.7.10.1; Basic fibroblast growth factor receptor 1; BFGFR; CD331; CD331 antigen; FGF Receptor; FGF receptor-1 precursor; FGFR; fgfr 1; FGFR-1; FGFR1/PLAG1 fusion; fibroblast growth factor receptor (FGFr) transmembrane form; Fibroblast growth factor receptor 1; fibroblast growth factor receptor FGFR-1 secreted form; FLT-2; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; N-sam; Proto-oncogene c-Fgr; unnamed protein product

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Gene Aliases: bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR; FGFR-1; FGFR1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM; OGD

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UniProt ID: (Human) P11362

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Entrez Gene ID: (Human) 2260

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity fibroblast growth factor-activated receptor activity protein binding ATP binding heparin binding kinase activity transferase activity fibroblast growth factor binding SH2 domain binding identical protein binding protein homodimerization activity receptor-receptor interaction
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade skeletal system development angiogenesis ureteric bud development in utero embryonic development organ induction neuron migration epithelial to mesenchymal transition positive regulation of mesenchymal cell proliferation chondrocyte differentiation protein phosphorylation brain development salivary gland morphogenesis sensory perception of sound cell proliferation positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway mesenchymal cell proliferation gene expression regulation of gene expression positive regulation of phospholipase activity positive regulation of macromolecule metabolic process negative regulation of gene expression regulation of phosphate transport positive regulation of neuron projection development cell migration peptidyl-tyrosine phosphorylation orbitofrontal cortex development ventricular zone neuroblast division cell projection assembly lung development embryonic limb morphogenesis midbrain development neuron projection development fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development inner ear morphogenesis outer ear morphogenesis middle ear morphogenesis chordate embryonic development positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration ear development cellular response to fibroblast growth factor stimulus regulation of cell differentiation positive regulation of cell differentiation positive regulation of neuron differentiation positive regulation of cell cycle protein autophosphorylation phosphatidylinositol-mediated signaling paraxial mesoderm development regulation of lateral mesodermal cell fate specification cell maturation blood vessel morphogenesis generation of neurons skeletal system morphogenesis mesenchymal cell differentiation stem cell differentiation regulation of epithelial cell proliferation regulation of phosphorus metabolic process positive regulation of protein kinase B signaling calcium ion homeostasis cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation auditory receptor cell development branching involved in salivary gland morphogenesis lung-associated mesenchyme development regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling vitamin D3 metabolic process diphosphate metabolic process cementum mineralization stem cell proliferation regulation of primary metabolic process positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway negative regulation of fibroblast growth factor production regulation of postsynaptic density assembly positive regulation of mitotic cell cycle DNA replication response to sodium phosphate positive regulation of vascular endothelial cell proliferation positive regulation of stem cell proliferation positive regulation of parathyroid hormone secretion positive regulation of endothelial cell chemotaxis regulation of extrinsic apoptotic signaling pathway in absence of ligand
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