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Invitrogen

GNAI1/GNAI2/GNAI3 Recombinant Rabbit Monoclonal Antibody (HL2092)

View all (2) GNAI1/GNAI2/GNAI3 antibodies

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Product Details

MA5-50378

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat, Zebrafish

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL2092

Immunogen

Recombinant fragment of human GNAI3.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3094420

Target Information

GNAI1/GNAI2/GNAI3 are genes that encode for the G protein alpha inhibiting activity subunit. These proteins play a crucial role in signal transduction pathways, particularly in the inhibition of adenylyl cyclase. They are involved in various physiological processes, including neurotransmitter release, hormone secretion, and regulation of smooth muscle contraction. Mutations in these genes have been associated with various diseases, including hypoparathyroidism, pituitary adenoma, and cardiovascular disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Adenylate cyclase-inhibiting G alpha protein; G alpha inhibitory type 2 (a); G alpha inhibitory type 2 (b); G protein; G protein alpha subunit; G(i) alpha-3; Galpha i1a; Galpha i3; Gi1 protein alpha subunit; GNAI2; GTP-binding protein (G-alpha-i2); GTP-binding protein alpha subunit; GTP-binding regulatory protein Gi alpha-2 chain; guanine nucleotide binding protein (G protein), alpha inhibiting 1; guanine nucleotide binding protein (G protein), alpha inhibiting 2; guanine nucleotide binding protein (G protein), alpha inhibiting 3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; guanine nucleotide binding protein, alpha inhibiting 1; guanine nucleotide binding protein, alpha inhibiting 2; guanine nucleotide binding protein, alpha inhibiting 3; Guanine nucleotide binding, protein, alpha inhibiting polypeptide 3; guanine nucleotide-binding protein (G) alpha subunit; guanine nucleotide-binding protein alpha-i subunit; guanine nucleotide-binding protein G(i) subunit alpha; Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding protein G(i) subunit alpha-3; guanine nucleotide-binding protein G(i), alpha-1 subunit; guanine nucleotide-binding protein G(i), alpha-2 subunit; guanine nucleotide-binding protein G(k) subunit alpha; guanine nucleotide-binding regulatory protein alpha-inhibitory subunit; heterotrimeric guanine nucleotide-binding protein 1A; heterotrimeric guanine nucleotide-binding protein 1B; heterotrimeric guanine nucleotide-binding protein 1C; HG1B/HG1C/HG1A; sGi2; unnamed protein product

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Gene Aliases: 87U6; AI158965; ARCND1; ARCODS; AU046200; AW537698; BPGTPB; C76432; Galphai2; Galphai3; Gi; Gia; Gialpha1; GIP; GIP3A; Gnai-1; Gnai-2; Gnai-3; GNAI1; GNAI2; GNAI2B; GNAI3; H_LUCA15.1; H_LUCA16.1; HG1A; HG1B; HG1C; NEDHISB; zgc:63957

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UniProt ID: (Human) P63096, (Human) P04899, (Human) P08754, (Rat) P10824, (Mouse) B2RSH2, (Rat) P04897, (Mouse) P08752, (Rat) P08753, (Mouse) Q9DC51

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Entrez Gene ID: (Human) 2770, (Human) 2771, (Human) 2773, (Rat) 25686, (Mouse) 14677, (Rat) 81664, (Mouse) 14678, (Rat) 25643, (Mouse) 14679, (Zebrafish) 393946, (Zebrafish) 100006888

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Function(s)
nucleotide binding magnesium ion binding G-protein coupled receptor binding GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding adenylate cyclase regulator activity adenylate cyclase inhibitor activity hydrolase activity guanyl nucleotide binding GDP binding G-protein beta/gamma-subunit complex binding D2 dopamine receptor binding G-protein coupled serotonin receptor binding metal ion binding signal transducer activity GTPase activating protein binding protein domain specific binding heterotrimeric G-protein
Process(es)
signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting serotonin receptor signaling pathway neuropeptide signaling pathway response to prostaglandin E response to peptide hormone positive regulation of cholesterol biosynthetic process negative regulation of insulin secretion cell division regulation of mitotic spindle organization chemokine-mediated signaling pathway T cell migration positive regulation of relaxation of smooth muscle cellular response to forskolin positive regulation of protein localization to cell cortex adenosine receptor signaling pathway negative regulation of adenylate cyclase activity G-protein coupled acetylcholine receptor signaling pathway gamma-aminobutyric acid signaling pathway response to nutrient cell proliferation positive regulation of cell proliferation positive regulation of cell migration positive regulation of superoxide anion generation positive regulation of urine volume negative regulation of calcium ion-dependent exocytosis modulation of synaptic transmission negative regulation of synaptic transmission regulation of calcium ion transport positive regulation of ERK1 and ERK2 cascade negative regulation of adrenergic receptor signaling pathway positive regulation of vascular smooth muscle cell proliferation positive regulation of neural precursor cell proliferation negative regulation of apoptotic signaling pathway positive regulation of macroautophagy GTP metabolic process metabolic process cell cycle activation of MAPKK activity G-protein coupled glutamate receptor signaling pathway regulation of heart contraction intracellular signal transduction vesicle fusion negative regulation of secretion
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