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Invitrogen
Lamin B1 Monoclonal Antibody (C4)
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FIGURE: 1 / 1
Lamin B1 Antibody (MA5-50963) in WB
Western blot analysis of Lamin B1 in various lysates. Samples were incubated with Lamin B1 monoclonal antibody (Product # MA5-50963) using a dilution of 2 μg/mL followed by HRP-Linked Caprine Anti-Mouse IgG secondary antibody at a dilution of 0.2 µg/mL. Lane 1: Human Lung lysate; Lane 2: 293T cell lysate; Lane 3: Rabbit Lung lysate.
Product Details
MA5-50963
Product Specifications
Species Reactivity
Human,
Rabbit
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
C4
Immunogen
Recombinant Human LMNB1 protein, Ser52-Gly233 (Accession #P20700)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
200 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Lamin B1 is a key member of the nuclear lamina structure, encoded by the LMNB1 gene. It is part of the B-type lamins, ubiquitously expressed across all mammalian cells, providing structural integrity and mechanical support by forming a meshwork along the inner nuclear membrane. Lamin B1 is involved in maintaining the shape and stability of the nucleus, playing a critical role in cellular processes such as genome organization, DNA replication, and transcription regulation. The lamin filaments are type V intermediate filament proteins, enabling the nucleus to withstand mechanical stress and preserve its functionality. Lamin B1's expression and dynamics vary during cell differentiation, influencing gene regulation. Its location within the euchromatin-enriched section of the genome suggests potential roles in chromatin organization and the epithelial-to-mesenchymal transition. Governed by complex interactions with other proteins, lamin B1 is integral to cellular architecture and health, with variations in its levels linked to developmental and disease processes. Recent studies have highlighted the importance of understanding the role and dynamics of lamin B1 in human-induced pluripotent stem cells and germ layer cells, offering insights into differentiation-dependent changes and their implications for nuclear structure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: lamin B; Lamin-B1; MGC111419; unnamed protein product
Gene Aliases: ADLD; ADLDAT; LMN; LMN2; LMNB; LMNB1; MCPH26
UniProt ID: (Human) P20700
Entrez Gene ID: (Human) 4001, (Rabbit) 100346094
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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