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Invitrogen

Apolipoprotein J Monoclonal Antibody (D19)

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Apolipoprotein J Monoclonal Antibody (D19)

Product Details

MA5-51107

Applications
Tested Dilution
Publications

Western Blot (WB)

0.01-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5-20 µg/mL
-
Product Specifications

Species Reactivity

Pig

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

D19

Immunogen

Recombinant Pig CLU protein, Ile229-Glu446 (Accession #Q29549)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

200 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.05% Proclin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3091310

Target Information

Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Aging associated protein 4; apo j; Apo J a; Apo J alpha; Apo J b; Apo J beta; Apo J α; Apo J β; Apo Ja; Apo Jb; ApoJ a; ApoJ alpha; ApoJ b; ApoJ beta; ApoJ α; ApoJ β; ApoJa; ApoJb; CLI; Clusterin; Clusterin alpha / beta chain; Complement associated protein SP40; Complement cytolysis inhibitor; CP40; GP80; HGNC:2095; Ku70-binding protein 1 (KUB1); MGC24903; Sulfated glycoprotein 2 (SGP2); Testosterone repressed prostate message 2 (TPRM2B)

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Gene Aliases: CLU

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UniProt ID: (Pig) Q29549

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Entrez Gene ID: (Pig) 397025

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Function(s)
beta-amyloid binding protein binding ATPase activity ubiquitin protein ligase binding macromolecular complex binding tau protein binding low-density lipoprotein particle receptor binding unfolded protein binding misfolded protein binding
Process(es)
cell morphogenesis microglial cell activation immune complex clearance response to virus protein import negative regulation of protein complex assembly positive regulation of protein complex assembly central nervous system myelin maintenance positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of tumor necrosis factor production regulation of cell proliferation positive regulation of apoptotic process positive regulation of nitric oxide biosynthetic process positive regulation of receptor-mediated endocytosis protein stabilization positive regulation of NF-kappaB transcription factor activity chaperone-mediated protein complex assembly response to misfolded protein chaperone-mediated protein folding microglial cell proliferation intrinsic apoptotic signaling pathway regulation of beta-amyloid clearance positive regulation of neuron death positive regulation of beta-amyloid formation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of beta-amyloid formation regulation of neuronal signal transduction positive regulation of tau-protein kinase activity positive regulation of neurofibrillary tangle assembly negative regulation of response to endoplasmic reticulum stress negative regulation of cellular response to thapsigargin negative regulation of cellular response to tunicamycin negative regulation of amyloid fibril formation positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of intrinsic apoptotic signaling pathway
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