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Invitrogen
NAMPT Recombinant Rabbit Monoclonal Antibody (5R7Y4)
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FIGURE: 1 / 5
NAMPT Antibody (MA5-51275) in IHC (P)
Immunohistochemistry analysis of NAMPT in paraffin-embedded human colon carcinoma. Samples were incubated with NAMPT Recombinant monoclonal antibody (Product # MA5-51275) using a dilution of 1:1, 000 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
MA5-51275
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
5R7Y4
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human PBEF/Visfatin/NAMPT (NP_005737.1).
Conjugate
Form
Liquid
Concentration
0.87 mg/mL
Amount
87 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VSRSTQAPLI IRPDSGNPLD TVLKVLEILG KKFPVTENSK GYKLLPPYLR VIQGDGVDIN TLQEIVEGMK QKMWSIENIA FGSGGGLLQK LTRDLLNCSF K
Target Information
Visfatin, also known as pre-B cell colony-enhancing factor, is an adipocytokine that is abundantly secreted by visceral adipose tissue, with insulin mimetic effects. Visfatin mimics insulin signaling by binding to the insulin receptor and reducing glucose release from liver cells, while stimulating glucose utilization in adipocytes and myocytes. Visfatin is also invoved in enhancement of cell proliferation, biosynthesis of nicotinamide mono-and dinucleotide and glucose homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp666B131; EC 2.4.2.12; MGC117256; NAmPRTase; Nicotinamide phosphoribosyltransferase; PBEF; Pre-B cell-enhancing factor; pre-B-cell colony enhancing factor 1; Pre-B-cell colony-enhancing factor 1; Pre-B-cell colony-enhancing factor 1 homolog; unnamed protein product; Visfatin
Gene Aliases: 1110035O14Rik; AI314458; AI480535; NAmPRTase; NAMPT; PBEF; PBEF1; VF; VISFATIN
UniProt ID: (Human) P43490, (Mouse) Q99KQ4, (Rat) Q80Z29
Entrez Gene ID: (Human) 10135, (Mouse) 59027, (Rat) 297508
cytokine activity
protein binding
transferase activity
transferase activity, transferring glycosyl groups
identical protein binding
nicotinamide phosphoribosyltransferase activity
nicotinate-nucleotide diphosphorylase (carboxylating) activity
drug binding
protein homodimerization activity
transferase
NADP biosynthetic process
nicotinamide metabolic process
inflammatory response
signal transduction
cell-cell signaling
circadian rhythm
positive regulation of cell proliferation
insulin receptor signaling pathway
NAD biosynthetic process
positive regulation of gene expression
pyridine nucleotide biosynthetic process
circadian regulation of gene expression
NAD salvage
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
adipose tissue development
positive regulation of ERK1 and ERK2 cascade
positive regulation of smooth muscle cell proliferation
positive regulation of nitric-oxide synthase biosynthetic process
female pregnancy
response to organic cyclic compound
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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