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Invitrogen
SEMA3A Recombinant Rabbit Monoclonal Antibody (7M10D0)
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FIGURE: 1 / 1
SEMA3A Antibody (MA5-51333) in WB
Western blot analysis of SEMA3A in various lysates. Samples were incubated with SEMA3A Recombinant monoclonal antibody (Product # MA5-51333) using a dilution of 1:20,000 followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
MA5-51333
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
7M10D0
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 582-771 of human Semaphorin 3A (NP_006071.1).
Conjugate
Form
Liquid
Concentration
0.055 mg/mL
Amount
5.5 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ERIIYGVENS STFLECSPKS QRALVYWQFQ RRNEERKEEI RVDDHIIRTD QGLLLRSLQQ KDSGNYLCHA VEHGFIQTLL KVTLEVIDTE HLEELLHKDD DGDGSKTKEM SNSMTPSQKV WYRDFMQLIN HPNLNTMDEF CEQVWKRDRK QRRQRPGHTP GNSNKWKHLQ ENKKGRNRRT HEFERAPRSV
Target Information
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: collapsin 1; collapsin-1; MGC133243; Sema D; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; Sema III; semaphorin D; Semaphorin III; semaphorin L; Semaphorin-3A; Semaphorin-D; unnamed protein product
Gene Aliases: coll-1; COLL1; HH16; Hsema-I; Hsema-III; SEMA1; SEMA3A; SEMAD; SEMAIII; SEMAL; SemD
UniProt ID: (Human) Q14563, (Mouse) O08665
Entrez Gene ID: (Human) 10371, (Mouse) 20346
neural crest cell migration
neuron migration
nervous system development
axon guidance
motor neuron axon guidance
negative regulation of neuron projection development
facial nerve structural organization
trigeminal nerve structural organization
nerve development
olfactory bulb development
branchiomotor neuron axon guidance
cell differentiation
positive regulation of cell migration
forebrain development
positive regulation of JNK cascade
sympathetic nervous system development
regulation of axon extension involved in axon guidance
axon extension involved in axon guidance
sensory system development
negative chemotaxis
axonogenesis involved in innervation
sympathetic ganglion development
semaphorin-plexin signaling pathway
sympathetic neuron projection extension
sympathetic neuron projection guidance
basal dendrite arborization
neural crest cell migration involved in autonomic nervous system development
regulation of heart rate
apoptotic process
multicellular organism development
axonal fasciculation
negative regulation of epithelial cell migration
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
negative regulation of axon extension
ventral trunk neural crest cell migration
dendrite morphogenesis
negative regulation of axon extension involved in axon guidance
dichotomous subdivision of terminal units involved in salivary gland branching
trigeminal ganglion development
semaphorin-plexin signaling pathway involved in neuron projection guidance
semaphorin-plexin signaling pathway involved in axon guidance
neural crest cell migration involved in sympathetic nervous system development
facioacoustic ganglion development
positive regulation of male gonad development
positive regulation of neuron migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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