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Invitrogen
RASA1 Recombinant Rabbit Monoclonal Antibody (6W10G6)
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FIGURE: 1 / 2
RASA1 Antibody (MA5-55332) in WB
Western blot analysis of lysates from mouse brain, using RASA1 Recombinant Monoclonal Antibody (Product # MA5-55332) at 1:500 dilution followed by a HRP-conjugated Goat anti-Rabbit IgG (H+L) secondary antibody at 1:10,000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Product Details
MA5-55332
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
6W10G6
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human RASA1.
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
RRID
Product Specific Information
Immunogen Sequence: KSGSYLIRES DRRPGSFVLS FLSQMNVVNH FRIIAMCGDY YIGGRRFSSL SDLIGYYSHV SCLLKGEKLL YPVAPPEPVE DRRRVRAILP YTKVPDTDEI S
Target Information
TACC1 is located on 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors. TACC family members, TACC1, TACC2, and TACC3, map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 4,8, and 10. Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation. Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog, D-TACC. It has been shown that D-TACC is necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GAP; GTPase-activating protein; p120 RAS GTPase activating protein; p120-rasGAP; p120GAP; Ras GTPase-activating protein 1; Ras p21 protein activator; RAS p21 protein activator (GTPase activating protein) 1; triphosphatase-activating protein; unnamed protein product
Gene Aliases: CM-AVM; CMAVM; CMAVM1; GAP; p120; p120GAP; p120RASGAP; PKWS; RASA; RASA1; RASGAP
UniProt ID: (Human) P20936
Entrez Gene ID: (Human) 5921, (Mouse) 218397
phosphotyrosine binding
GTPase activity
GTPase activator activity
receptor binding
protein binding
potassium channel inhibitor activity
enzyme binding
GTPase binding
glycoprotein binding
platelet-derived growth factor receptor binding
kinase binding
protein kinase binding
receptor tyrosine kinase binding
protein complex binding
ion channel binding
GTPase-activating protein
mitotic cytokinesis
angiogenesis
vasculogenesis
negative regulation of cell-matrix adhesion
negative regulation of cell adhesion
signal transduction
regulation of cell shape
regulation of actin filament polymerization
intracellular signal transduction
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
ephrin receptor signaling pathway
blood vessel morphogenesis
system development
regulation of RNA metabolic process
regulation of intracellular signal transduction
positive regulation of protein phosphorylation
cellular response to platelet-derived growth factor stimulus
positive regulation of GTPase activity
positive regulation of glucose import
negative regulation of Ras protein signal transduction
positive regulation of fibroblast proliferation
positive regulation of peptidyl-tyrosine phosphorylation
cellular response to epidermal growth factor stimulus
activation of GTPase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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