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Invitrogen
PLA2R1 Recombinant Rabbit Monoclonal Antibody (7I4Z1)
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FIGURE: 1 / 1
PLA2R1 Antibody (MA5-55526) in WB
Western Blot analysis of various lysates using PLA2R1 Recombinant Monoclonal Antibody (Product # MA5-55526) at 1:900 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1:10,000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Product Details
MA5-55526
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
7I4Z1
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
1.05 mg/mL
Amount
105 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
RRID
Product Specific Information
Immunogen Sequence: YQYDVPWLFY QDAEYLFHTF ASEWLNFEFV CSWLHSDLLT IHSAHEQEFI HSKIKALSKY GASWWIGLQE ERANDEFRWR DGTPVIYQNW DTGRERTVNN Q
Target Information
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 180 kDa secretory phospholipase A2 receptor; C-type lectin domain family 13 member C; M-type receptor; mannose receptor, C type 2; phospholipase A2 receptor 1, 180kD; phospholipase A2 receptor 1, 180kDa; phospholipase A2, group IB, pancreas, receptor; PLA2-I receptor; PLA2-R; putative soluble PLA2 receptor precursor; Secretory phospholipase A2 receptor
Gene Aliases: CLEC13C; Mrc2; PLA2-R; Pla2g1br; PLA2G1R; PLA2IR; PLA2R; PLA2R1
UniProt ID: (Human) Q13018, (Mouse) Q62028
Entrez Gene ID: (Human) 22925, (Rat) 295631, (Mouse) 18779
positive regulation of cytokine production
endocytosis
receptor-mediated endocytosis
positive regulation of DNA damage response, signal transduction by p53 class mediator
reactive oxygen species metabolic process
positive regulation of arachidonic acid secretion
replicative senescence
oxidative stress-induced premature senescence
negative regulation of arachidonic acid secretion
positive regulation of glomerular visceral epithelial cell apoptotic process
cytokine production
negative regulation of phospholipase A2 activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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