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Invitrogen
BST-2 Monoclonal Antibody (K29052_18D3)
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FIGURE: 1 / 1
BST-2 Antibody (MA5-55797) in WB
Western blot analysis of BST-2 in 15 µg of HeLa. Sample was run on 6-18% SDS-PAGE under reducing conditions, blotted onto nitrocellulose membrane, and peroxidase conjugated rabbit anti-mouse IgG (Light chain specific) was used as the secondary antibody. BST-2 band was visualized using ECL Western Blotting Substrate. Incubation with primary BST-2 monoclonal antibody (Product # MA5-55797) at a dilution of 1 µg/mL was used.
Product Details
MA5-55797
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
K29052_18D3
Immunogen
Recombinant human BST2 (immunogen range is 71-160).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
Product Specific Information
Sequence of this protein is as follows: QQELTEAQKG FQDVEAQAAT CNHTVMALMA SLDAEKAQGQ KKVEELEGEI TTLNHKLQDA SAEVERLRRE NQVLSVRIAD KKYYPSSQDS
Target Information
BST2 (CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein that is involved in the development and growth of B-cells. The surface expression of BST2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line. BST2 is highly expressed during B-cell development, from pro-B precursors to plasma cells, T-cells, monocytes, NK cells and DCs (at protein level), and myeloma cells. Research studies have shown that BST2 also functions as an inhibitor of retrovirus release from human cells whose activity is antagonized by the HIV-1 accessory protein, Vpu. While BST2 causes retention of virions on cell surfaces or endocytosis into BST2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release, an activity that may represent a potential therapeutic strategy for the treatment of HIV/AIDS. Another disease associated with BST2 dysfunction is stomatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antiviral factor tetherin; Bone marrow stromal antigen 2; BST-2; CD317; HM1.24 antigen; NPC-A-7; PDCA-1; Tetherin; unnamed protein product
Gene Aliases: BST2; CD317; HM1.24; TETHERIN
UniProt ID: (Human) Q10589
Entrez Gene ID: (Human) 684
immune system process
negative regulation of plasmacytoid dendritic cell cytokine production
response to virus
negative regulation of cell growth
negative regulation of cell migration
regulation of actin cytoskeleton organization
response to interferon-gamma
response to interferon-alpha
response to interferon-beta
B cell activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of viral genome replication
innate immune response
defense response to virus
positive regulation of leukocyte proliferation
negative regulation of intracellular transport of viral material
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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