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Invitrogen
PRDX5 Monoclonal Antibody (K16265_6D9)
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FIGURE: 1 / 3
PRDX5 Antibody (MA5-55942) in IHC (P)
Immunohistochemistry analysis of PRDX5 in paraffin-embedded kidney tissue. Sample was incubated with PRDX5 monoclonal antibody (Product # MA5-55942) at a dilution of 5 µg/mL (RT, 1 hour). Antigen was retrieved through addition of boiling Tris/EDTA buffer pH 9 in a pressure cooker for 3 min. Endogenous peroxidase activity was quenched by incubating the sections with 3% H2O2 for 30 min at room temperature. Po... View More
Product Details
MA5-55942
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
K16265_6D9
Immunogen
Recombinant human PRDX5 (immunogen range is 53-214).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
Product Specific Information
Sequence of this protein is as follows: MAPIKVGDAI PAVEVFEGEP GNKVNLAELF KGKKGVLFGV PGAFTPGCSK THLPGFVEQA EALKAKGVQV VACLSVNDAF VTGEWGRAHK AEGKVRLLAD PTGAFGKETD LLLDDSLVSI FGNRRLKRFS MVVQDGIVKA LNVEPDGTGL TCSLAPNIIS QL
Target Information
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alu co-repressor 1; Alu corepressor 1; Antioxidant enzyme B166; AOEB166; epididymis secretory protein Li 55; hAOEB166; alkyl hydroperoxide reductase; thioredoxin peroxidase; Liver tissue 2D-page spot 71B; Peroxiredoxin V; Peroxiredoxin-5, mitochondrial; Peroxisomal antioxidant enzyme; PLP; PMP20; PRDX5; Prx-V; Prx5; Thioredoxin peroxidase PMP20; thioredoxin reductase; Thioredoxin-dependent peroxiredoxin 5; TPx type VI
Gene Aliases: ACR1; AOEB166; B166; HEL-S-55; PLP; PMP20; PRDX5; PRDX6; prx-V; PRXV; SBBI10
UniProt ID: (Human) P30044
Entrez Gene ID: (Human) 25824
RNA polymerase III regulatory region DNA binding
peroxidase activity
receptor binding
protein binding
thioredoxin peroxidase activity
antioxidant activity
oxidoreductase activity
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
peroxynitrite reductase activity
thioredoxin-dependent peroxiredoxin activity
inflammatory response
response to oxidative stress
negative regulation of transcription from RNA polymerase III promoter
positive regulation of collagen biosynthetic process
cellular response to oxidative stress
cellular response to reactive oxygen species
hydrogen peroxide catabolic process
negative regulation of apoptotic process
cell redox homeostasis
negative regulation of oxidoreductase activity
regulation of apoptosis involved in tissue homeostasis
cellular oxidant detoxification
reactive nitrogen species metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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