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Invitrogen
MOV10 Recombinant Rabbit Monoclonal Antibody (24GB575)
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FIGURE: 1 / 4
MOV10 Antibody (MA5-57488) in ICC/IF
Immunocytochemical staining of MOV10 in HeLa cells using MOV10 Recombinant Monoclonal Antibody (Product # MA5-57488) at a 1:1,1000 dilution. Nuclei were stained blue with DAPI; MOV10 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar: 20 μm.
Product Details
MA5-57488
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
24GB575
Immunogen
A synthesized peptide derived from human Mov10 (aa 850-880)
Conjugate
Form
Liquid
Concentration
2 mg/mL
Amount
200 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol. May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). Exhibits antiviral activity against dengue virus (DENV) (PubMed:27974568). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Armitage homolog; capping protein (actin filament) muscle Z-line, alpha 1; functional spliceosome-associated protein 113; Helicase MOV-10; Moloney leukemia virus 10 protein; Mov10 RISC complex RNA helicase; Mov10, Moloney leukemia virus 10; Mov10, Moloney leukemia virus 10, homolog; Putative helicase MOV-10; unnamed protein product
Gene Aliases: C77703; Capza1; fSAP113; Gb110; KIAA1631; Mov-10; MOV10
UniProt ID: (Human) Q9HCE1, (Mouse) P23249
Entrez Gene ID: (Human) 4343, (Rat) 310756, (Mouse) 17454
biological_process
mRNA cleavage involved in gene silencing by miRNA
negative regulation of transposition, RNA-mediated
gene silencing by RNA
posttranscriptional gene silencing by RNA
gene silencing by miRNA
defense response to virus
positive regulation of mRNA catabolic process
3'-UTR-mediated mRNA destabilization
transposable element silencing by mRNA destabilization
regulation of neuron projection arborization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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