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Invitrogen
RALBP1 Recombinant Rabbit Monoclonal Antibody (24GB875)
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FIGURE: 1 / 4
RALBP1 Antibody (MA5-57676) in ICC/IF
Immunocytochemical staining of RALBP1 in Hela cells using RALBP1 Recombinant Monoclonal Antibody (Product # MA5-57676) at a 1:1,1000 dilution. Nuclei were stained blue with DAPI; RALBP1 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Product Details
MA5-57676
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
24GB875
Immunogen
A synthesized peptide derived from human RALBP1 (aa 200-265)
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
Can specifically activate hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDC2 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 76 kDa Ral-interacting protein; Cytocentrin; Dinitrophenyl S-glutathione ATPase; DNP-SG ATPase; Ral-interacting protein 1; RalA-binding protein 1; RalBP1; RIP; unnamed protein product
Gene Aliases: RALBP1; RIP1; RLIP; RLIP1; RLIP76
UniProt ID: (Human) Q15311, (Rat) Q62796, (Mouse) Q62172
Entrez Gene ID: (Human) 10928, (Rat) 84014, (Mouse) 19765
nucleotide binding
GTPase activator activity
protein binding
ATP binding
xenobiotic-transporting ATPase activity
glutathione S-conjugate-exporting ATPase activity
transmembrane transporter activity
small GTPase binding
ATPase activity, coupled to transmembrane movement of substances
xenobiotic transporter activity
ATPase activity
Ral GTPase binding
ATPase activity, coupled to movement of substances
Rac GTPase binding
G-protein modulator
protein-binding activity modulator
GTPase-activating protein
positive regulation of protein phosphorylation
receptor-mediated endocytosis
chemotaxis
signal transduction
small GTPase mediated signal transduction
regulation of Cdc42 protein signal transduction
regulation of GTPase activity
positive regulation of GTPase activity
regulation of small GTPase mediated signal transduction
transmembrane transport
positive regulation of mitochondrial fission
doxorubicin transport
drug transmembrane export
transport
endocytosis
mitotic spindle organization
mitotic nuclear division
metabolic process
negative regulation of smooth muscle cell proliferation
cell division
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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