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Invitrogen
Factor VII Monoclonal Antibody (321621)
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Product Details
MA5-61141
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
321621
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Coagulation Factor VII, Ala39-Pro444
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Coagulation factor VII is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in F7 production can cause coagulopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Coagulation factor VII; coagulation factor VII (serum prothrombin conversion accelerator); eptacog alfa; Factor 7; Factor7; FVII coagulation protein; preprofactor VIIb; Proconvertin; Serum prothrombin conversion accelerator; SPCA; unnamed protein product
Gene Aliases: F7; SPCA
UniProt ID: (Human) P08709
Entrez Gene ID: (Human) 2155
response to hypoxia
positive regulation of leukocyte chemotaxis
proteolysis
response to stress
blood coagulation
hemostasis
circadian rhythm
response to hormone
response to carbon dioxide
positive regulation of platelet-derived growth factor receptor signaling pathway
protein processing
positive regulation of blood coagulation
positive regulation of cell migration
organ regeneration
response to nutrient levels
positive regulation of TOR signaling
response to estradiol
response to vitamin K
response to genistein
response to estrogen
regulation of body fluid levels
positive regulation of positive chemotaxis
response to growth hormone
response to cholesterol
response to thyroid hormone
response to thyroxine
response to Thyroid stimulating hormone
response to 2,3,7,8-tetrachlorodibenzodioxine
response to astaxanthin
response to thyrotropin-releasing hormone
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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